| Name | 6-Hydroxyflavanone |
| Description | 6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A receptors. 6-Hydroxyflavanone has anti-injury sensory properties in a streptozotocin-induced diabetic neuropathy model. in a streptozotocin-induced diabetic neuropathy model with anti-injury sensory properties. |
| In vivo | 6-Hydroxyflavanone (6-HF) (6-HF) (5, 30, and 60 mg/kg ) inhibited the COX-2 and 5-LOX enzymes significantly. It substantially reduced heat nociception in a hot plate analgesia meter, as well as carrageenan-induced paw edema in rodent models. The authors discovered that 6-HF exhibited anti-nociception properties in a streptozotocin-induced diabetic neuropathy (DIN) model. According to the findings of this study, 6-HF demonstrated the ability to diminish inflammation caused by diabetes, as well as to exert an anti-nociceptive.[3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 2.4 mg/mL (10 mM), Sonication is recommended.
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| Keywords | GABAReceptor | GABAA | GABA Receptor | COX-2 | 6-Hydroxyflavanone | 6Hydroxyflavanone | 6 Hydroxyflavanone | 5-LOX |
| Inhibitors Related | p-Hydroxybenzaldehyde | Urethane | Acetaminophen | Deferiprone | Phenidone | Valproic Acid | Gallic Acid Monohydrate | Diclofenac Potassium | Paradol | Phenylbutazone | Revaprazan hydrochloride | Dihydromyricetin |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Flavonoid Natural Product Library | Traditional Chinese Medicine Monomer Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
United States
