| Name | [6]-Gingerol |
| Description | [6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues. |
| Cell Research | [6]-gingerol stock (20 mg/mL) is prepared in ethanol and the working concentrations are prepared by diluting this stock in dimethyl sufoxide (DMSO). For MTT assay, 5×103 cells/well of human colon cancer cells and 104 cells/well of mouse IECs are seeded in 96-well plates. Cells are treated with [6]-gingerol for 48 h,72 h or 96 h before performing MTT assay and for 16 h before Annexin-V staining[1]. |
| In vitro | [6]-Gingerol selectively inhibits proliferation and induces apoptosis in colon cancer cells while sparing normal colon cells. It modulates cell signaling by down-regulating phorbol myristate acetate-induced phosphorylation of ERK1/2 and JNK MAP kinases and reducing AP-1 transcription factor activation, with minimal impact on p38 MAP kinase phosphorylation and NF-kappa B activation[1]. Moreover, [6]-gingerol enhances intestinal barrier function and diminishes proinflammatory responses in DSS-treated Caco-2 monolayers, partly by activating AMPK[2]. Additionally, it significantly reduces osteosarcoma cell viability in a dose-dependent manner, increases sub-G1 cell cycle arrest, and activates caspase cascades while adjusting Bcl2 and Bax protein levels[3]. |
| In vivo | In animal studies, [6]-gingerol effectively mitigates DSS-induced colitis symptoms by reversing body weight loss, decreasing intestinal bleeding, and preventing colon shortening. It also inhibits the DSS-induced increase in proinflammatory cytokines (IL-1β, TNFα, and IL-12)[2]. |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc. : Soluble
DMSO : 50 mg/mL (169.84 mM), Sonication is recommended.
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| Keywords | AMP-activated protein kinase | Apoptosis | inhibit | [6] Gingerol | [6]-Gingerol | AMPK | [6]Gingerol | Inhibitor |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | Metronidazole | Sorafenib | Tributyrin | Salicylic acid | Oleic acid | Chitosan oligosaccharide |
| Related Compound Libraries | Marine Natural Product Library | Selected Plant-Sourced Compound Library | Kinase Inhibitor Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library | Anti-Cancer Active Compound Library |
![[6]-Gingerol](/ProductImageEN1/2024-11/Large/b7d42100-9f96-4565-aea0-2742a854aee9.png)
United States
