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Exemestane
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Alias: Exemestane,Aromasin,Exemestan
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Purity : 99%min
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CAS Registry Number: 107868-30-4
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Einecs No: N/A
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Molecular formula: C20H24O2
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Molecular weight:296.4
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Grade : Pharmaceutical Grade
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Storage: Shading, confined preservation
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Usage : pharmaceutical material, etc
Description:
1 . emestane is a steroidal Aromatase Inhibitor (AI) that is most commonly known as Aromasin. In fact, the
Aromasin brand name is the only pharmaceutical grade brand of the Exemestane AI due to the tight
patent Upjohn has maintained on the product. While tightly controlled by the pharmaceutical giant,
Aromasin is available in numerous countries around the globe.
2 . Aromasin was first released on the U.S. market in 2000 after shortly gaining FDA approval a few
months prior in 1999. The primary purpose of use as with most AI's would be to combat breast cancer in
post-menopausal women. Shortly after, the AI would begin to gain a lot of popularity among anabolic
steroid users for its ability to protect against estrogenic related side effects. This action is very similar to
the older and more popular AI's in Arimidex and Femara It would also gain a fair amount of popularity in
Post Cycle Therapy (PCT) plans among steroid users. It was not the first AI to gain such popularity but
would prove to be a little more advantageous for this purpose than most AI's
3 . Aromasin is officially classified as a steroidal suicide Aromatase Inhibitor, and carries the ability to
inhibit the aromatase enzyme, which is responsible for the production or conversion of testosterone to
estrogen. Aromasin has the ability to block aromatization, which in turn inhibits the production of estrogen,
and thereby lowers the body's serum estrogen levels. This will prove useful to breast cancer patients as
breast cancer often feeds off the estrogen hormone. It will also prove useful to the anabolic steroid user.
Specifications :
TEST ITEMS
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SPECIFICATION
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RESULTS
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Description
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White Crystalline Powder
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White Powder
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Identification
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Positive
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Positive
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Assay(by HPLC)
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98.0~102.0%
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99.64%
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Absorbance(E1cm)
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465~495
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482.5
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Melting Point
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191~195℃
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193.5~195.0℃
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Loss On Drying
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0.5%max
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0.19%
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Specific Rotation
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+288°~ +298°
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+290.2°
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Residue On Ignition
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0.1%max
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0.03%
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Related Substances
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Total:1.5%max
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<1.3%
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Residue Solvents
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0.2%max
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0.10%
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Heavy Metals
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20PPm max
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<10PPm
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Conclusion
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The specification conform with USP35
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Applications:
1 . Many anabolic steroids have the ability to increase estrogen levels due to the aromatase process,
specifically the conversion of testosterone to estrogen. This can lead to gynecomastia and water
retention. Excess water retention can also promote high blood pressure when it becomes severe. Steroids
that do not carry a strong estrogenic nature can also cause these effects, most notably gynecomastia if
they carry a progestin nature. A prime example would be Nandrolone, which while it aromatizes only does
so at 20% the rate of testosterone. However, it also carries a strong progestin nature, and progesterone
has been well noted for carrying the ability to stimulate the estrogenic mechanism in the mammary tissue.
By administering Aromasin during the use of anabolic steroids, this will inhibit the aromatase process,
lower estrogen levels and protect the individual from estrogenic side effects. How effective is Aromasin
The product claims on average to have the ability to lower serum estrogen levels by 85%.
2 . This is dependent on the individual and, also, the amount of aromatizing compounds the person is
running. Generally, a good starting dose is 12.5mg ED (every day) or 25mg EOD (every other day). The
user must utilize blood work to see how their body is reacting at the starting dosage they choose and then
adjust as needed. Experienced anabolic steroid users will usually find a dose they like and stick to it with
no problems. As I said already, if you start noticing joint issues then the dose should be lowered; on the
other hand, if you start noticing any estrogen related sides, such as puffy or sensitive breasts or water
retention, it's time to increase the dosage.