| Product Name: |
Carbamazepine |
| Synonyms: |
5H-Dibenz[b,f]azepine-5-carboxamine;5H-Dibenzo[b,f]azepine-5-carboxamide;Biston;Calepsin;Carbamazepen;Carbamezepine;Carbazepine;Carbelan |
| CAS: |
298-46-4 |
| MF: |
C15H12N2O |
| MW: |
236.27 |
| EINECS: |
206-062-7 |
| Product Categories: |
Pharmaceutical;Acids and Derivatives;Heterocycles;Active Pharmaceutical Ingredients;APIs;Pharmaceutical raw material;TEGRETOL;Pharmaceutical Chemicals;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Isotope Labelled Compounds |
| Mol File: |
298-46-4.mol |
 |
| |
| Carbamazepine Chemical Properties |
| Melting point |
189-192 °C |
| Boiling point |
378.73°C (rough estimate) |
| density |
1.1099 (rough estimate) |
| refractive index |
1.5906 (estimate) |
| Fp |
9℃ |
| storage temp. |
2-8°C |
| solubility |
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble29mg/mL |
| form |
Crystals |
| color |
Almost white |
| Water Solubility |
pract. insoluble |
| Merck |
14,1781 |
| CAS DataBase Reference |
298-46-4(CAS DataBase Reference) |
| NIST Chemistry Reference |
Carbamazepine(298-46-4) |
| Hazard Codes |
Xn,T,F |
| Risk Statements |
42/43-22-20/21/22-39/23/24/25-23/24/25-11 |
| Safety Statements |
37-24-22-36/37/39-36-45-36/37-16 |
| RIDADR |
UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany |
2 |
| RTECS |
HN8225000 |
| HS Code |
29339900 |
| Hazardous Substances Data |
298-46-4(Hazardous Substances Data) |
| Toxicity |
LD50 orally in mice, rats: 3750, 4025 mg/kg (Stenger, Roulet) |
| Provider |
Language |
| Carbamazepine |
English |
| ACROS |
English |
| |
| Carbamazepine Usage And Synthesis |
| Overview |
Carbamazepine (CBZ) is an irninostilbene derivative, structurally similar to the tricyclic antidepressants. Chemically. CBZ is a neutral, liposoluble compound that can easily pass the bloodlbrain barrier and other membranes in the body. Developed and marketed for the treatment of epileptic seizures and trigeminal neuralgia, CBZ has been utilized more and more frequently in the last decade to treat psychiatric disorders.
Carbamazepine was first evaluated as a potential treatment in manic depressive psychosis by Takezaki and Hanaoka (1971)[1], and Okuma et al. (1973)[2]. In 1979, Okuma et al.[3] performed the first double-blind trial of carbamazepine in comparison with the antipsychotic chlorpromazine in mania and found that 70% and 60% of patients improved respectively. A further placebo-controlled double-blind study replicated the antimanic properties of carbamazepine under controlled circumstances (Ballenger and Post, 1980). There have since been many studies demonstrating the efficacy of carbamazepine in treating the acute manic and depressive symptoms of bipolar disorder, as well as in prophylaxis[4, 5]. |
| Carbamazepine Basic information |
| Overview Indication Dosage and administration Plasma levels monitoring Cautions Pharmacodynamics Interactions Special populations Mode of action Psychiatric use Adverse reactions and precaution References |
Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA.
Our main production base is located in Xuzhou industry park. We produce a wide range of organics including Active pharmaceutical ingredients(APIs), Veterinary, Indole derivatives, Aromatics, Fluorine, Boronic acids, organocatalysts, chiral building blocks, heterocyclic compounds. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.
Our R&D team masters core technology for process-design of target building block as well as Tailor-made fine chemicals. Our manufactory specialised in extreme temperature conditions (-100ºC to +300ºC), hydrogenations reaction under high pressure, suzuki coupling reaction, photochemical reaction, Mitsunobu reactions, enantioselective reactions and asymmetric synthesis.
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