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Flunixin meglumin in stock GMP Factory
- Min. Order1KG
- PurityUSP37/ EP8 /BPV 2012
- Cas No42461-84-7
- Supply Ability1000 metric tons
- Update time2020-06-02
Product Name | Flunixin meglumin in stock GMP Factory |
CAS No | 42461-84-7 |
EC-No | |
Min. Order | 1KG |
Purity | USP37/ EP8 /BPV 2012 |
Supply Ability | 1000 metric tons |
Release date | 2020/06/02 |
PLS contact Ms Ella Lee - Deputy Sales Manager
- ProName: Flunixin meglumin
- CasNo: 42461-84-7
- Molecular Formula: C14H11F3N2O2
- Appearance: White crystalline powder
- Application: Veteinary pharmaceutical
- DeliveryTime: 10days
- PackAge: 25kg 10kg,5kgs
- Port: Chinese main port
- ProductionCapacity: 500 Kilogram/Week
- Purity: 98%
- Storage: Dry and cool condition
- Transportation: By air by sea or express
- LimitNum: 1 Kilogram
- Related Substances: 98%
- Residue on Ignition: 0.3%
- Heavy Metal: 0.3%
Package: 25.0kg net drum
main uses: mammalian anti-inflammatory analgesia, can alleviate muscle abnormalities caused by inflammation and pain, treatment of diarrhea, tremor, colitis, respiratory diseases, endotoxin-induced mastitis, arthritis, fever, diarrhea, tremor, eye infections, etc.
Product Name: Flunixin Meglumine
Chemical Name: 1-deoxy-1-(methylamino)-d-glucitol 2-[2-methyl-3-(perfluoromethyl)anilino]nicotinate
Cas No.: 42461-84-7
Molecular Formula: C21H28F3N3O7
Molecular Weight: 491.46
flunixin meglumine is a potent, non-narcotic, non-steroidal analgesic agent with anti-inflammatory and antipyretic activity. it is a potent inhibitor of the enzyme cyclooxygenase. it has demonstrated biological activity in the following areas:
- analgesia (loss of pain). flunixin meglumine demonstrated potent analgesic activity in laboratory studies with mice, rats, and monkeys. parenterally, flunixin meglumine showed anti-writhing activity in mice equal to pentazocine and was more potent than meperidine and codeine. in the rat yeast paw test, it was significantly more potent than pentazocine, meperidine, and codeine. in monkeys, flunixin meglumine produced analgesia comparable to a clinically effective dose of morphine. in the horse, it has been shown to be an effective treatment of pain associated with colic. in contrast to narcotic agents, its analgesic effects were not antagonized by naloxone, tolerance did not develop, and cross-tolerance to codeine did not occur. these results show that flunixin meglumine is an effective analgesic in animals, and drug dependence liability does not occur.
- anti-inflammatory. flunixin meglumine showed anti-inflammatory activity in laboratory animals. a dose-related reduction in edema was recorded four hours after treatment. in the horse, anti-inflammatory activity was demonstrated in lameness models, showing relief of pain by improving stride length and reducing swelling.
- potency. based on manufacturers' recommendations in the horse, parenteral banamine (flunixin meglumine), on a milligram per milligram basis, is four times as potent as phenylbutazone and twice as potent as ketoprofen.
product name: flunixin meglumine
chemical name: 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid meglumine salt
formula/structure: c14h11f3n2o2.c7h17no5
molecular weight: 491.46
cas no.: 42461-84-7
flunixin meglumine ;flunixin meglumine is a potent, non-narcotic, non-steroidal analgesic agent with anti-inflammatory and antipyretic activity. it is a potent inhibitor of the enzyme cyclooxygenase. it has demonstrated biological activity in the following areas:
- analgesia (loss of pain). flunixin meglumine demonstrated potent analgesic activity in laboratory studies with mice, rats, and monkeys. parenterally, flunixin meglumine showed anti-writhing activity in mice equal to pentazocine and was more potent than meperidine and codeine. in the rat yeast paw test, it was significantly more potent than pentazocine, meperidine, and codeine. in monkeys, flunixin meglumine produced analgesia comparable to a clinically effective dose of morphine. in the horse, it has been shown to be an effective treatment of pain associated with colic. in contrast to narcotic agents, its analgesic effects were not antagonized by naloxone, tolerance did not develop, and cross-tolerance to codeine did not occur. these results show that flunixin meglumine is an effective analgesic in animals, and drug dependence liability does not occur.
esting items |
specifications |
results |
appearance |
white to almost white, crystalline powder |
conforms |
solubility |
freely soluble in water and methanol, paractically insoluble in acetone |
conforms |
identification 1 |
infrared absorption:197m;u ltraviolet absorption:197u |
conforms |
identification 2 |
water: free soluble;ethanol(96%):free soluble ethyl acetate: practically insoluble |
conforms |
melting point |
137~140℃ |
137.5~138.5 |
ph |
5 %(w/v)water solution:7.0~9.0 |
8.2 |
related substances |
2-chloropyridine-3carboxylic acid ≤0.2% |
undetected |
2-methyl-3-(trifluoromethyl)aniline ≤0.2% |
undetected |
|
ethyl 2-chloropyridine-3-carboxylate ≤0.2% |
undetected |
|
ethyl 2-[[2-methyl-3-(trifluoromethyl) phenyl]amino]pyridine-3-carboxylate ≤0.2% |
undetected |
|
impurities |
1. single impurity: not more than 0.2% |
conforms |
2. unknown impurity: not more than 0.2% |
conforms |
|
total impurities(1~2): not more than 0.5% |
conforms |
|
specific optical rotation |
-9.0°~ -12.0° |
-10.3° |
solvent residue |
isopropanol: not more than 0.5% |
conforms |
|
ethanol: not more than 0.5% |
conforms |
bacterial endotoxins |
not more than 4.54 eu/mg |
0.1 eu/mg |
loss on drying |
≤0.5% |
0.2% |
sulphated ash |
≤0.1% |
0.05% |
residue on ignition |
≤0.2% |
0.1% |
colour of solution |
clear,less coloured than reference solution y6,b.p.(vet) |
conforms |
clarification |
1.2g funixin meglumine/8.8g water |
transparent |
explanation |
micronisarion 200±20um |
|
assay (hplc) |
99.0~101.0% |
99.64% |
conclusion |
comply with usp 37/ep7/bpv2012 |
|
Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA.
Our main production base is located in Xuzhou industry park. We produce a wide range of organics including Active pharmaceutical ingredients(APIs), Veterinary, Indole derivatives, Aromatics, Fluorine, Boronic acids, organocatalysts, chiral building blocks, heterocyclic compounds. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.
Our R&D team masters core technology for process-design of target building block as well as Tailor-made fine chemicals. Our manufactory specialised in extreme temperature conditions (-100ºC to +300ºC), hydrogenations reaction under high pressure, suzuki coupling reaction, photochemical reaction, Mitsunobu reactions, enantioselective reactions and asymmetric synthesis.
Think Chemistry,Think CHemWill
Factory Plant Address:
High-Tech Industrial park,Chemical Economical Development Zone,Xuzhou, Jiangsu-Province, P.R.China
Shanghai office: (Export Department)
Address: 16FL., INDUSTRY & COMMERCIAL BUILDING, NO.45 YAN’AN ROAD(E), 200002, SHANGHAI, CHINA
---any inquiries will be replied within 12 hours.
---golden manufactory under iso/gmp with large stock.
---dedication to quality,we have strict quality control system.
---oem/odm available.
---sample is available for your evaluation & formulation development.
PLS contact
Ms Ella Lee - Deputy Sales Manager
Company Profile Introduction
Over 30 years experience in the chemical industry, Chemwill Asia Industrial co.,Ltd is one of the leading GMP complied manufacturer of Organic compounds in CHINA. Our main production base is located in Jiangsu province. We produce a wide range of organics including Active pharmaceutical ingredients(APIs), Veterinary, Indole derivatives, Aromatics, Fluorine, Boronic acids, organocatalysts, chiral building blocks, heterocyclic compounds. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place. Our advantageous business including: - Intermediate using for Pharmaceuticals - Active ingredient for Pharmaceutical and animal health (Human APIs and Veterinary APIs) - Fluorine, boronic acids, unnatural amino acids, cross linkers,chiral building blocks - Intermediate using for advanced performance materials - Monomer & polymers, high performance, photosensitive and specialty chemicals - Electro chemical materials(Lithium Battery, Photoresist, semiconductor, IT-related chemicals) * Custom synthesis from the laboratory scale to commercial production. * Contract research, custom manufacturing and contract-manufacture Ms Ella Lee - Deputy Sales Manager Phone: +86 -21-51086038 Email: chemwill_asia@126.com;chemwill@hotmail.com To learn more about our factory, PLS visit: www.chemwill.com