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ChemicalBook Product Catalog Biochemical Engineering Plant extracts Cinobufagin

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Cinobufagin

$ 1.00 /1KG

Min. Order1g
Purity99%
Cas No470-37-1
Supply Ability100KG
Update time2019-07-06

career henan chemical co

career henan chemical co

7YR

China

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Chemical Properties

Product Name	Cinobufagin
CAS No	470-37-1
EC-No
Min. Order	1g
Purity	99%
Supply Ability	100KG
Release date	2019/07/06

Cinobufagin Basic information

Description References

Product Name:	Cinobufagin
Synonyms:	RARECHEM BK HC T302;TRANS-3-PHENYLPROPENOIC ACID;TRANS-3-BENZENEPROPENOIC ACID;TRANS-CINNAMYLIC ACID;16-beta)-bet;22-dienolide,16-(acetyloxy)-14,15-epoxy-3-hydroxy-,(3-beta,5-beta,15-bufa-2;cinobufagine;AKOS B004228
CAS:	470-37-1
MF:	C26H34O6
MW:	442.55
EINECS:	205-398-1
Product Categories:	Steroids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:	470-37-1.mol

Cinobufagin Chemical Properties

Melting point	133 °C(lit.)
Boiling point	300 °C(lit.)
Fp	>230 °F
storage temp.	2-8°C

Safety Information

Hazard Codes	Xi,T+,Xn
Risk Statements	36/37/38-26/27/28-42/43-20/22
Safety Statements	26-36-45-36/37/39-22-24/25
RIDADR	UN 2811 6.1/PG 1
WGK Germany	3
RTECS	GD7850000
HazardClass	6.1(a)
PackingGroup	II
HS Code	29322090

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

Cinobufagin Usage And Synthesis

Description	Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans, having similar effects to digitalis and used in traditional Chinese medicine. It has potential antineoplastic activity and now is widely used in clinical practice, especially in anti-liver cancer. It has benn found to suppress cancer cell proliferation and cause apoptosis in cancer cells via a sequence of apoptotic modulators, including mitochondrial Bax and cytosolic chromosome c, and caspases 3, 8, and 9.
References	1. https://en.wikipedia.org/wiki/Cinobufagin 2. https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=689412 3. http://www.yourdictionary.com/cinobufagin 4. https://www.medchemexpress.com/cinobufagin.html
Uses	Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was show

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