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ChemicalBook Product Catalog 4'-N-benzoylstaurosporine

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4'-N-benzoylstaurosporine

$ 2.00 /1kg

Min. Order1kg
Purity99%
Cas No120685-11-2
Supply Ability100kg
Update time2019-07-06

career henan chemical co

career henan chemical co

7YR

China

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Chemical Properties

Product Name	4'-N-benzoylstaurosporine
CAS No	120685-11-2
EC-No
Min. Order	1kg
Purity	99%
Supply Ability	100kg
Release date	2019/07/06

4'-N-benzoylstaurosporine Basic information

Product Name:	4'-N-benzoylstaurosporine
Synonyms:	4'-N-benzoylstaurosporine;Midostaurin, Benzoylstaurosporine, 4'-N-Benzoylstaurosporine, CGP 41251;Benzamide, N-((9S,10R,11R,13R)-2,3,9,10,11,12-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-J)(1,7)benzodiazonin-11-yl)-N-methyl-;Benzamide, N-(2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-1-oxo-8,12-epoxy-1H,8H-2,7B,12A-triazadibenzo(A,G)cyclonona(cde)trinden-10-yl)-N-methyl-, (8alpha,9beta,10beta,12alpha)-;Benzoylstaurosporine;Cgp 41 251;Cgp 41251;Cgp-41251
CAS:	120685-11-2
MF:	C35H30N4O4
MW:	570.646
EINECS:	999-999-2
Product Categories:	antibiotic
Mol File:	120685-11-2.mol

4'-N-benzoylstaurosporine Chemical Properties

Melting point	235-260℃
storage temp.	Store at 2-8
solubility	Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml), 100% ethanol (2.5 mg/ml), and DMF (20 mg/ml).

Safety Information

Hazard Codes	T
Risk Statements	36/37/38

MSDS Information

4'-N-benzoylstaurosporine Usage And Synthesis

Uses	Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
Definition	ChEBI: An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.
Biological Activity	Broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms ( α , β , γ ), PDFR β , VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.

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