ChinaChemical Properties
| Product Name | DL-Menthol |
| CAS No | 89-78-1 |
| EC-No | 216-074-4 |
| Min. Order | 1 g |
| Purity | 99% |
| Supply Ability | 100KG |
| Release date | 2019/07/06 |
AD68
| DL-Menthol Basic information |
| Flavors and fragrances First aid of poisoning Detection method Chemical properties Uses |
| Product Name: | DL-Menthol |
| Synonyms: | (1R,2S,5R)-rel-2-Isopropyl-5-Methylcyclohexanol;(+/-)-Menthol raceMic, >=98.0% (GC);menthol crystal extract;89-78-1;(1α,2β,5α)-5-methyl-2-(1-methylethyl)cyclohexanol;2-(1-methylethyl)-5-methyl-cyclohexanol;2-isopropyl-5-methyl-cyclohexano;5alpha-Methyl-2beta-(1alpha-methylethyl)cyclohexanol |
| CAS: | 89-78-1 |
| MF: | C10H20O |
| MW: | 156.27 |
| EINECS: | 216-074-4 |
| Product Categories: | phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Flavor & essential oil;Inhibitors;Monoterpenoids;Terpenes and Terpenoids (Isoprenoids);Alcohols;Building Blocks;C9 to C10;Chemical Synthesis;Nutrition Research;Ocimum basilicum (Basil);Organic Building Blocks;Oxygen Compounds;Phytochemicals by Chemical Classification;Phytochemicals by Plant (Food/Spice/Herb);Sambucus nigra (Elderberry);API Intermediate;chemical reagent;pharmaceutical intermediate |
| Mol File: | 89-78-1.mol |
 |
|
| DL-Menthol Chemical Properties |
| Melting point | 34-36 °C(lit.) |
| Boiling point | 216 °C(lit.) |
| alpha | -2 º (c=10, EtOH) |
| density | 0.89 g/mL at 25 °C(lit.) |
| vapor pressure | 0.8 mm Hg ( 20 °C) |
| refractive index | 1.4615 |
| FEMA | 2665 | MENTHOL RACEMIC |
| Fp | 200 °F |
| storage temp. | Store below +30°C. |
| solubility | 456mg/l |
| form | Crystalline Solid |
| color | Colorless to white |
| Water Solubility | insoluble |
| Merck | 14,5837 |
| BRN | 3194263 |
| CAS DataBase Reference | 89-78-1(CAS DataBase Reference) |
| NIST Chemistry Reference | DL-Menthol(89-78-1) |
| EPA Substance Registry System | Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel-(89-78-1) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 37/38-41-36/37/38 |
| Safety Statements | 36/37/39-24/25-36-26-39 |
| RIDADR | UN 1888 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | OT0350000 |
| TSCA | Yes |
| HS Code | 29061100 |
| Hazardous Substances Data | 89-78-1(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 3180 mg/kg (Jenner) |
| MSDS Information |
| Provider | Language |
|---|---|
| p-Menthan-3-ol | English |
| DL-Menthol Usage And Synthesis |
| Flavors and fragrances | Menthol is a cyclic terpene alcohol flavors and fragrances with its appearance exhibiting colorless needle or shuttle columnar crystal or white crystalline powder. It has special aroma of mint with its taste being hot at first but then being cool later. It exhibit neutralizing reaction in the ethanol solution, being extremely easily soluble in ethanol, chloroform, petroleum ether, ether, liquid paraffin or volatile oil and being very slightly soluble in water. Its molecular structure contains three asymmetric carbon atoms, so it has four stereoisomers with their aroma intensity and type and cool feeling being different. There are two common types: natural menthol and synthetic menthol. Natural menthol is a kind of saturated ring alcohol obtained through the freezing & crystallization, separation and refinement of peppermint oil with the optical rotation being L; synthetic menthol is made from taking lemon eucalyptus oil as raw material. Its main component can be manufactured from the ring closing reaction of citronellal to obtain isopulegol, followed by hydrogenation, or through the synthesis of thymol from m-cresol with catalytic hydrogenation resulting in four menthol mixture of isomers with the precise vacuum distillation obtaining defined synthetic menthol, being racemate with no optical rotation. It has bactericidal and anti-corrosion effect and can be used as the fragrance of toothpaste, perfume, beverages and confectionery. In the medicine, it can be used for making cool oil, painkillers, mouthwash, and so on. The main applications are as follows: 1. Menthol can act on the skin sensory nerve end, making the skin surface to produce cool feeling, achieving the purpose of itching prevention. Topical administration to the affected area can be used for the treatment of urticaria, prurigo, prickly heat, rash, neurodermatitis and skin pruritus and so on. 2. It can be used for the treatment of headache, nasal congestion and sore throat. This product has pleasant aroma and has curing effect on treating cold and wind heat. It has effects of refreshing the mind and clearing the throat. |
| First aid of poisoning | Topical application of menthol have effects of promoting blood circulation and anti-inflammatory, anti-itching and can be applied to anti-inflammatory, antipruritic, analgesic and reducing swelling and so on. 【Diagnosis】 1. Oral administration of large amount of menthol or inhaling of large amount of menthol gas can lead to gastrointestinal symptoms such as nausea, vomiting and abdominal pain as well as nervous system symptoms such as excitement, tremor, dizziness, vertigo, hand and foot numbness, swing gait, lethargy, breathing changes, facial flushing, reduced blood pressure, muscle rigidity or relaxation, occasional being not able to speak; children, after taking a large dose, can have coma. But it can be generally restored within a few hours. 2. Patients allergic to this chemical can get with eczema with unbearable itching feeling. 3. Small infants, sometimes due to nasal mint liquid or ointment, can get glottis spasm, accompanied with bruising and suffocation as well as secretion of large amounts of mucus. In severe cases, it may be occurred of respiratory and cardiac arrest. 【Treatment principles】 1. Gastric lavage; conduct catharsis with salt cathartic. Avoid using fats and oils. 2. Apply intravenous rehydration to promote excretion. 3. In cases of allergic symptoms, we should treat with antihistamines such as diphenhydramine, chlorpheniramine, etc.; if necessary, we can apply hydrocortisone or dexamethasone intravenously. |
| Detection method | (1) Chemical qualitative method ① take 1 g of this product, add 20 mL of sulfuric acid to dissolve it, so the reaction mixture becomes orange-red. After 24h, there will be colorless oil layer of non-menthol aroma precipitated out (the distinction from thymol). ② take 50 mg of this product, add 1mL of ice acetic acid to dissolve it; Addition of 6 drops of sulfuric acid and 1 drop of nitric acid to the cold mixture will lead to only slightly yellow color (the difference from thymol). (2) thin-layer chromatography: take appropriate amount of menthol and dissolve in anhydrous ethanol, make a solution containing 6 mg menthol per mL for spotting. TLC: silica gel G manual plating, make it dry; have it subjected to activation in 105 °C for 1 hour and standby. Developing agent A: n-hexane-ethyl acetate-benzene (43: 4.5: 4); Developing agent B: petroleum-ether-ethyl acetate-chloroform (25: 2.5: 5.5). Coloration reagent: 5% vanillin ethanol solution-concentrated sulfuric acid (100: 6). Coloration: heating at 105 ℃ for 6~10min, exhibiting a circular blue spots. (3) Determination of physical constants: melting point: 42 ℃~44 °C. Specific rotation: take this product for accurately weighing; add ethanol to make a solution of 0.1 g/mL. Measure according to the method, the specific rotation is-49 ° ~-50 °. (4) non-volatile matter: take 2 g of this product and place it in the pre-weighed evaporating dish; have it heated in the water bath so it is slowly evaporated; dried at 105 ℃ to constant weight with the leftover residue not exceeding 1mg. |
| Chemical properties | L-form appears as colorless needle crystal. The melting point is 42-43 °C; the boiling point is 216 °C, the specific rotation:-51 °-45 °; the flash point: 93 °C; the relative density: 0.8810; it is soluble in ethanol and is miscible with oil. It has cool, fresh, pleasant mint characteristic aroma with sweet spiky gas. It gives people a cold feeling with aroma penetrating through the hair, but not lasting. The taste is also fresh sweet cool taste. |
| Uses | It is mainly used in medicine, toothpaste, toothpaste and mouthwash with its cool taste being able to enhance the smell of peppermint oil, having effect of refreshing the brain as well as disinfection effects. It can also be used as spices to be applied to the colognes. Application of appropriate amount of low-grade soap and detergent fragrance such as roses, geraniol, lavender and fragrant has effects of enhancing the tone and aroma. It can also be applied to food flavors and flavor for wine and tobacco. In medicine, it can be applied to the cooling oil, painkillers, etc., it can also be used for making toothpaste, toothpowder, candy, beverages, spices and so on. How to use: it can be used for formulating the food flavor in the food flavor plant; or also be directly added or dissolved in alcohol to be added to the food flavoring. Storage requirements: placed in a cool place, sealed for storage. Avoid wind and rain. |
| Chemical Properties | colorless to white crystalline solid |
| Uses | A chemical which triggers cold-sensitive TRPM8 receptors in the skin neurons in vitro. |
| Uses | In liqueurs, confectionery, perfumery, cigarettes, cough drops, and nasal inhalers. |
| General Description | White crystalline solid with a peppermint odor and taste. |
| Air & Water Reactions | Insoluble in water. |
| Reactivity Profile | DL-Menthol is incompatible with butyl chloral hydrate, camphor, phenol, chloral hydrate, Exalgine, betanaphthol, resorcinol or thymol in triturations; potassium permanganate, chromium trioxide and pyrogallol. DL-Menthol is also incompatible with strong oxidizers. |
| Hazard | Irritant to mucous membranes on inhalation. |
| Fire Hazard | DL-Menthol is combustible. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;
