Name | 5α-Pregnane-3β,6α-diol-20-one |
Description | 5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite derived from progesterone, synthesized by androgen-responsive prostate cancer cells under starvation conditions. |
In vitro | Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts [1]. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather dependent on 3β-HSD activity [2]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 100 mg/mL (298.96 mM), Sonication is recommended.
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Keywords | 5αPregnane3β,6αdiol20one | 5α Pregnane 3β,6α diol 20 one | 5a-Pregnane-3b,6a-diol-20-one | 5α-Pregnane-3β,6α-diol-20-one | inhibit | Inhibitor | 5alpha-Pregnane-3beta,6alpha-diol-20-one |
Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Natural Product Library | Anti-Prostate Cancer Compound Library | NO PAINS Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Covalent Inhibitor Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |