| Name | 5-Ethynyl-2'-deoxyuridine |
| Description | 5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].Like 5-bromo-2’-deoxyuridine (BrdU), EdU is incorporated into DNA during active DNA synthesis. It can then be detected using a fluorescent azide probe and copper catalysis using 1,3-dipolar cycloaddition.Modified nucleosides, including EdU, can be cytotoxic when added to cells for prolonged periods[2].5-Ethynyl-2'-deoxyuridine (EdU) staining is a fast, sensitive and reproducible method to study cell proliferation in the central nervous system[3] |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 8 mg/mL (31.72 mM), Sonication is recommended.
DMSO : 120 mg/mL (475.77 mM), Sonication is recommended.
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| Keywords | 5 Ethynyl 2' deoxyuridine | PROTAC Linkers | inhibit | Inhibitor | 5Ethynyl2'deoxyuridine | 5-Ethynyl-2'-deoxyuridine |
| Inhibitors Related | N-Boc-4-pentyne-1-amine | Diethylene glycol bis(p-toluenesulfonate) | 6-Maleimidocapronic acid | Fmoc-8-amino-3,6-dioxaoctanoic acid | Bis-Tos-PEG4 | Boc-NH-PEG4-CH2COOH | 11-Aminoundecanoic acid | 1,3-Dibromo-5,5-dimethylhydantoin | 1-Bromo-6-chlorohexane | Ac4ManNAz |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Human Metabolite Library | Nucleotide Compound Library |
United States
