| CAS: | 2353-33-5 |
| MF: | C8H12N4O4 |
| MW: | 228.21 |
| EINECS: | 219-089-4 |
| Product Categories: | Inhibitors;Deoxycytidine;Anti-cancer&immunity;API;Bases & Related Reagents;Nucleotides;Inhibitor;Epigenetics;analog of cytosine;Intermediates & Fine Chemicals;Pharmaceuticals;2353-33-5 |
| Mol File: | 2353-33-5.mol |
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| 5-Aza-2'-deoxycytidine Chemical Properties |
| Melting point | ~200 °C (dec.) |
| alpha | D22 +68.5° (30 min) +57.8° (6 hr) (c = 0.5 in water) |
| Boiling point | 370.01°C (rough estimate) |
| density | 1.3771 (rough estimate) |
| refractive index | 1.6590 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | acetic acid/water (1:1): 50 mg/mL |
| form | Powder |
| pka | 14.02±0.60(Predicted) |
| color | White to Off-white |
| Merck | 14,2853 |
| BRN | 617982 |
| Stability: | Stable. May be light or air sensitive. Incompatible with strong oxidizing agents. |
| InChIKey | XAUDJQYHKZQPEU-KVQBGUIXSA-N |
| CAS DataBase Reference | 2353-33-5(CAS DataBase Reference) |
| EPA Substance Registry System | 5-Aza-2'-deoxycytidine (2353-33-5) |
| Description | Decitabine, 5-aza-2’-deoxycytidine, has been launched for the treatment of myelodysplastic syndromes (MDS). MDS are a set of hematologic disorders affecting the bone marrow that result in ineffective formation and development of blood cells. Furthermore, patients with MDS have a high risk of progressing to acute myeloid leukemia (AML). Traditional treatments include blood transfusions, hematopoietic growth factors, and prophylactic antibiotics, but these measures merely improve the quality of life with questionable effects on disease modification. While stem-cell transplantation is an aggressive, potentially curative approach, the advanced age or the other complicating health issues of most patients preclude them from considering this option. Recent advances in the underlying etiology of MDS, however, have led to the development of a new class of compounds known as ‘‘demethylating agents’’. Decitabine follows the successful introduction of the first DNA methyltransferase inhibitor azacitidine. |
| Chemical Properties | white crystalline powder |
| Originator | Pharmachemie (Netherlands) |
| Uses | Used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines. |
| Uses | Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively |
| Uses | 5-Aza-2′-deoxycytidine has been used as a demethylating agent in breast cancer cell line, chromatin, DNA and promoter region of p16 gene. |
| Definition | ChEBI: 5-aza-2'-deoxycytidine is a 2'-deoxyribonucleoside. |
| Brand name | Dacogen (Millot Laboratories, France). |
| General Description | Fine white crystalline powder. Used as a drug. |
| Air & Water Reactions | Probably light and air sensitive. Water soluble. Decomposes in aqueous solution at a rate that depends on pH: at pH 7 the drug is more stable than at pH 9, but is less stable than at pH 6. At pH 7 and 99°F, approximately 7% conversion occurs in 1 hour . |
| Reactivity Profile | 5-Aza-2'-deoxycytidine is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. |
| Fire Hazard | Flash point data for 5-Aza-2'-deoxycytidine are not available. 5-Aza-2'-deoxycytidine is probably combustible. |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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