product name : amantadine hcl
cas no: 665-66-7
mf: c10h15nh2.hcl
molecular weight: 187.71
appearance: white crystalline powder
content: 99%
usage of amantadine hcl
1) as anti-virus medicine
used to make intermediate of anti-virus medicine for treating a2 type flu virus, has antipyretic effect in the clinical pharmacology;
amend fremitus and anaesthesia of parkinson's disease symptom.
2) as pharmaceutical intermediate
amantadine hcl can be used as intermeditate to vildagliptin
3) as medicine to cure glaucoma
by blocking the nmda receptor-mediated apoptosis, amantadine hcl has a great protective effect against rgc , then reduce and delay apoptosis of retinal tissue.
4) raw material of catalyst
it can be as a raw material of catalyst to produce the new warm cataly, the applicant is very widely.
mechanism of action
antiviral the mechanism by which amantadine exerts its antiviral activity is not clearly understood. it appears to mainly prevent the release of infectious viral nucleic acid into the host cell by interfering with the function of the transmembrane domain of the viral m2 protein. in certain cases, amantadine is also known to prevent virus assembly during virus replication. it does not appear to interfere with the immunogenicity of inactivated influenza a virus vaccine.
storage and transportation
store in a tightly closed container. store in a cool, dry, ventilated area away from incompatible substances.
avoid to contact water or moisture during storing&transporting.
certificate of analysis
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items
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specification
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appearance
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white crystal or crystalline powder, odo(u)rless and bitter
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identification
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meets the requirements
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acidity
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ph 3.0~5.5
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clarity and color
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the solution should be clear and nearly colorless
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loss on drying
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≤0.5%
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residue on ignition
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≤0.1%
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heavy metals
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≤0.001%
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related substances
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any individual impurity 0.3%
total impurity 1.0%
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assay
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≥98.5%
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standard
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usp30
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China
