Chinese name: p-hydroxyphenylglycine
English name: DL-4-HYDROXYPHENYLGLYCINE
CAS: 938-97-6
EINECS number: 228-682-7
Molecular formula: C8H9NO3
MDL number: MFCD00065931
Molecular weight: 167.16
category
Biochemistry: Glycine derivatives
Appearance: Type R (type D) : crystallization, melting point 240℃ (decomposition), [α]-158.4° (C=1,1mol/L HCl). (+/-) type: flake crystal (water), insoluble in water, insoluble in ether, non-melting decomposition at 200℃.
Melting point: 229-230 °C
Boiling point: 365.8±32.0 °C(Predicted)
Density: 1.396± 0.06g /cm3(Predicted)
Storage conditions: Keep in dark place,Inert atmosphere,Room temperature
Solubility: Soluble in DMSO (very slight, heated), water (slight, heated, ultrasonic treatment)
Acidity coefficient (pKa) : 2.15±0.10(Predicted)
Form: solid
Color: White to light yellow
use
Intermediates of beta-lactam antibiotics such as ampicillin and cefoperazone (with type D).
Preparation method
P-methoxybenzaldehyde is reacted with sodium cyanide and ammonium bicarbonate in ethanol to produce p-methoxybenzhein, which is then hydrolyzed with sodium hydroxide solution to obtain p-methoxyphenylglycine, which is hydrolyzed with bromohydroacid to produce the product.
China
