8-Methoxypsoralen

$ 1.00 /1KG

Min. Order1G
Purity98%
Cas No298-81-7
Supply Ability100KG
Update time2019-07-06

career henan chemical co

7YR

China

Chemical Properties

Product Name	8-Methoxypsoralen
CAS No	298-81-7
EC-No
Min. Order	1G
Purity	98%
Supply Ability	100KG
Release date	2019/07/06

AD68

8-Methoxypsoralen Basic information

Description References

Product Name:	8-Methoxypsoralen
Synonyms:	2-g)(1)benzopyran-7-one,9-methoxy-7h-furo(;2-g][1]benzopyran-7-one,9-methoxy-7h-furo[;5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone;5-Benzofuranacrylicacid,6-hydroxy-7-methoxy-,δ-lactone;6-Hydroxy-7-methoxy-5-benzofuranacrylic acid gamma-lactone;6-hydroxy-7-methoxy-5-benzofuranacrylicaciddelta-lactone;6-hydroxy-7-methoxy-5-benzofuranacrylicacidelta-lactone;7-Furocoumarin
CAS:	298-81-7
MF:	C12H8O4
MW:	216.19
EINECS:	206-066-9
Product Categories:	Intermediates & Fine Chemicals;Pharmaceuticals;Cytochrome P450 isozyme;This product is manufactured in GMP workshop.;Aromatics;Heterocycles;API;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;OXSORALENE;Other APIs;Inhibitors
Mol File:	298-81-7.mol

8-Methoxypsoralen Chemical Properties

Melting point	148-150 °C(lit.)
Boiling point	276.6°C (rough estimate)
density	1.1344 (rough estimate)
refractive index	1.4270 (estimate)
storage temp.	-20°C Freezer, Under Inert Atmosphere
solubility	H2O: slightly soluble
form	Needle-Like Crystals or Powder
color	white to yellow
Water Solubility	PRACTICALLY INSOLUBLE
Merck	14,5988
BRN	196453
CAS DataBase Reference	298-81-7(CAS DataBase Reference)
NIST Chemistry Reference	Methoxsalen(298-81-7)
EPA Substance Registry System	7H-Furo[3,2-g][1] benzopyran-7-one, 9-methoxy-(298-81-7)

Safety Information

Hazard Codes	Xn,T
Risk Statements	22-43-46-45-34
Safety Statements	36/37-53-45-36/37/39-26
RIDADR	3216
WGK Germany	3
RTECS	LV1400000
F	10
TSCA	Yes
Hazardous Substances Data	298-81-7(Hazardous Substances Data)
Toxicity	LD50 i.p. in rats: 470 ±30 mg/kg (Hakim)

8-Methoxypsoralen Usage And Synthesis

Description

8-methoxypsoralen (also known as methoxsalen) is a naturally occurring furocoumarin compound existing in several species of plants such as Psoralea corylifolia. It is a photoactive substance that can form DNA adducts upon UVA irradiation. It is a drug used for the treatment of psoriasis, eczema, vitiligo, and some kinds of cutaneous lymphomas associated with the exposure of skin to the UVA or light from lamps or sunlight. Its mechanism of action is through inhibiting the synthesis of the deoxyribonucleic acid (DNA). After the activation, it can preferentially bind to the guanine and cytosine molecules of DNA, further leading to the cross-linking of DNA, thus inhibiting the DNA synthesis. It can further inhibit the RNA and protein synthesis at high concentration. It is extracted from Ammi majus.

Chemical Properties	Crystalline Solid
Uses	antipsoriatic, pigmentation agent
Uses	Naturally occurring analog of Psoralen (P839800). Use in treatment of psoriasis and mycosis fungoides.
Uses	For the treatment of psoriasis and vitiligo
Uses	Naturally occurring analog of psoralen. Use in treatment of psoriasis and mycosis fungoides
Uses	A potent suicide inhibitor of cytochrome P-450.
Definition	ChEBI: A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
General Description	Odorless white to cream-colored crystalline solid. Bitter taste followed by tingling sensation.
Air & Water Reactions	Sensitive to light and air. Insoluble in water.
Reactivity Profile	8-Methoxypsoralen is incompatible with strong oxidizing agents.
Fire Hazard	Flash point data for 8-Methoxypsoralen are not available; however, 8-Methoxypsoralen is probably combustible.