Oxolinic acid

$ 1.00 /1KG

Min. Order1G
Purity98%
Cas No14698-29-4
Supply Ability100KG
Update time2019-07-06

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Chemical Properties

Product Name	Oxolinic acid
CAS No	14698-29-4
EC-No
Min. Order	1G
Purity	98%
Supply Ability	100KG
Release date	2019/07/06

AD68

Oxolinic acid Basic information

Description References

Product Name:	Oxolinic acid
Synonyms:	1-ethyl-1,4-dihydro-6,7-methylenedioxy-4-oxo-3-quinolinecarboxylicacid;1-ethyl-6,7-methylenedioxo-4-quinoline-3-carboxlicacid;1-ethyl-6,7-methylenedioxy-4-quinolone-3-carboxylicacid;5-g)quinoline-7-carboxylicacid,5-ethyl-5,8-dihydro-8-oxo-3-dioxolo(4;5-g]quinoline-7-carboxylicacid,5-ethyl-5,8-dihydro-8-oxo-3-dioxolo[4;dioxacin;emyrenil;gramurin
CAS:	14698-29-4
MF:	C13H11NO5
MW:	261.23
EINECS:	238-750-8
Product Categories:	Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;veterinary medicine,APIs,pharmaceutical raw material;UTIBID;API
Mol File:	14698-29-4.mol

Oxolinic acid Chemical Properties

Melting point	314-316°C (dec.)
Boiling point	473℃
Fp	>110°(230°F)
storage temp.	2-8°C
solubility	Soluble in 0.5N NaOH with warming
form	Crystalline Powder
color	White
Sensitive	Light Sensitive
Merck	13,7014
Stability:	Stable. Combustible.
CAS DataBase Reference	14698-29-4(CAS DataBase Reference)
EPA Substance Registry System	1,3-Dioxolo[4,5- g]quinoline-7-carboxylic acid, 5-ethyl-5,8-dihydro-8-oxo- (14698-29-4)

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	22-24/25-60-36
WGK Germany	3
RTECS	JI5075000
F	10
Hazardous Substances Data	14698-29-4(Hazardous Substances Data)
Toxicity	LD50 in mice, rats (mg/kg): >6000, >2000 orally (Turner)

Oxolinic acid Usage And Synthesis

Description	Developed in Japan in the 1970s, oxolinic acid belongs to the family of quinolone antibiotic, which is a synthetic antimicrobial agent aiming at gram-negative bacteria, especially those responsible for urinary tract infections. It is also commonly used in clinical for microbiological antimicrobial susceptibility tests against gram negative microbial isolates, providing antibiotic treatment options for infected patients. It can serve as a selective agent in several types of isolation media, for example, to isolate Gardnerella vaginalis. Besides, oxolinic acid can be applied in agriculture, which has proved to be effective against the seed-borne pathogen, such as Burkholderia glumae, a bacteria inducing grain rot, sheath rot, seedling rot, and bacterial panicle blight. Oxolinic acid works by targeting DNA gyrase or topoisomerase II, enzymes vital for DNA synthesis, which ultimately inhibits DNA synthesis and cell division.
References	https://en.wikipedia.org/wiki/Oxolinic_acid http://www.toku-e.com/product/oxolinic_acid/ https://www.goldbio.com/product/3027/oxolinic-acid
Chemical Properties	Crystalline Solid
Uses	Oxolinic acid is a quinolone antibiotic used for studies on DNA winding and coiling and for studies on dopaminergic neurotransmission processes. It is used to study new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6′)Ib-cr, in Escherichia
Uses	Quinolone antibacterial.
Definition	ChEBI: A quinolinemonocarboxylic acid having the carboxy group at position 7 as well as oxo and ethyl groups at positions 4 and 1 respectively and a dioxolo ring fused at the 5- and 6-positions. A synthetic antibiotic, it is used in veterinary medicine for the tr atment of bacterial infections in cattle, pigs and poultry.