Methylene Blue trihydrate

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Methylene Blue trihydrate Basic information

Product Name:	Methylene Blue trihydrate
Synonyms:	METHYLTHIONINE CHLORIDE;METHYLTHIONINE CHLORIDE TRIHYDRATE;METHYLENE BLUE, CHLORIDE, TRIHYDRATE;METHYLENE BLUE CHLORIDE;METHYLENE BLUE HYDRATE;METHYLENE BLUE INDICATOR;METHYLENE BLUE TRIHYDRATE;METHYLENE BLUE TS
CAS:	7220-79-3
MF:	C16H24ClN3O3S
MW:	373.9
EINECS:	200-515-2
Product Categories:	Dyes and Pigments;Cytochemistry ProductsStains and Dyes;Hematology and Histology;M;Stains&Dyes, A to;API;Pharmaceuticals;Phenothiazine
Mol File:	7220-79-3.mol

Methylene Blue trihydrate Chemical Properties

Melting point	190 °C (dec.)(lit.)
density	0.98 g/mL at 25 °C
Fp	14 °C
storage temp.	Store at RT.
solubility	Soluble in water, chloroform; sparingly soluble in ethanol
form	Solid
pka	2.6, 11.2(at 25℃)
color	Green
Water Solubility	4 g/100 mL
λmax	668 nm, 609 nm
Merck	13,6085
Stability:	Stable. Incompatible with bases, reducing agents, strong oxidizing agents.
Biological Applications	Diagnosis of tauopathy,Alzheimer’s disease (AD),Pick’s disease; treating prophylaxis; dental materials
InChIKey	YAFGUSOAMIMROI-UHFFFAOYSA-M
CAS DataBase Reference	7220-79-3(CAS DataBase Reference)
EPA Substance Registry System	Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride, trihydrate(7220-79-3)

Safety Information

MSDS Information

Provider	Language
3,7-Bis(dimethylamino)phenothiazin-5-ium chloride	English
ACROS	English
ALFA	English

Methylene Blue trihydrate Usage And Synthesis

Chemical Properties	Dark green crystalline powder
Uses	antibacterial
Uses	Stain in bacteriology; reagent for several chemicals; as mixed indicator; as redox colorimetric agent. Targeting agent for melanoma.
General Description	Odorless or almost odorless dark green crystals with bronze luster or dark green crystalline powder. pH (1% solution in water) 3 to 4.5 .
Air & Water Reactions	Hygroscopic. Water soluble. Gives a blue solution in water.
Reactivity Profile	Methylene Blue trihydrate is incompatible with strong oxidizing agents, caustics, alkali metal iodides and reducing agents. Also incompatible with dichromates. Methylene Blue trihydrate forms double salts with many inorganic salts. Is bleached reversibly by (zinc + hydrochloric acid) or sodium hydrosulfite. In aqueous solution, Methylene Blue trihydrate is decolorized by zinc dust and dilute sulfuric acid, but the color is restored upon exposure to air and more rapidly upon addition of ammonium hydroxide.
Fire Hazard	Flash point data for Methylene Blue trihydrate are not available; however, Methylene Blue trihydrate is probably combustible.

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