Basic information General Description Pharmacology Indication Contraindication Mechanism of Action Information on Dosing Drug Interactions Lubiprostone Warnings Side Effects References Safety Related Supplier

ChemicalBook Product Catalog Biochemical Engineering Inhibitors Transmembrane Transporters CFTR activator Lubiprostone

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Lubiprostone

$ 1.00 /1KG

Min. Order1KG
Purity98%
Cas No136790-76-6
Supply Ability1
Update time2019-07-06

career henan chemical co

career henan chemical co

7YR

China

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Chemical Properties

Product Name	Lubiprostone
CAS No	136790-76-6
EC-No
Min. Order	1KG
Purity	98%
Supply Ability	1
Release date	2019/07/06

CR368

Product Name:	Lubiprostone
Synonyms:	Lubiprostone API;7-[(1r,4r,6r,9r)-4-(1,1-difluoropentyl)-4-hydroxy-8-oxo-5-oxabicyclo[4.3.0]non-9-yl]heptanoic acid;lubiprostone;(11a)-16,16-Difluoro-11-hydroxy-9,15-dioxo-prostan-1-oic Acid;Ru 0211;C13707;(11α)-16,16-Difluoro-11-hydroxy-9,15-dioxo-prostan-1-oic Acid;Prostan-1-oic acid, 16,16-difluoro-11-hydroxy-9,15-dioxo-, (11α)-
CAS:	136790-76-6
MF:	C20H32F2O5
MW:	390.4618864
EINECS:
Product Categories:	Inhibitors;Prostaglandin;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs
Mol File:	136790-76-6.mol

Lubiprostone Chemical Properties

Melting point	56-59°C
storage temp.	-20°C Freezer

Safety Information

MSDS Information

Lubiprostone Usage And Synthesis

Description	Marketed under the trade name Amitiza, Lubiprostone is a chloride channel activator which is mainly used for the treatment of idiopathic (due to an unknown cause) chronic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. Lubiprostone is an oral medication approved by the FDA in January 2006. The mechanism of action of lubiprostone is the same as chloride channel activator. It functions by binding and activating ClC-2 chloride channels in the apical membrane of the gastrointestinal epithelium, which produces an efflux of chloride-rich fluid secretion. The increased amounts of secretions are effective to soften the stool, increase motility, promote spontaneous bowel movements (SBM), and speed up transit of stool in the colon. Therefore, the relevant symptoms, such as abdominal pain and bloating, can be reduced.
References	https://en.wikipedia.org/wiki/Lubiprostone http://www.medicinenet.com/lubiprostone/article.htm https://www.drugbank.ca/drugs/DB01046 https://pubchem.ncbi.nlm.nih.gov/compound/157920#section=Top
Chemical Properties	White Solid
Uses	A locally acting chloride channel activator for the treatment of gastrointestinal disorders
Uses	Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1. It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, increase gastrointestinal transit, and improve symptoms of constipation.

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