Name | 4,5-Dimethoxycanthin-6-one |
Description | 4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae) with antimicrobial activity against Staphylococcus aureus and its drug-resistant strains. It is a potent, non-competitive inhibitor of CYP1A2-mediated phenacetin O-deethylation (IC50: 1.7 μM, Ki: 2.6 μM) and a potent inhibitor of cyclic adenosine monophosphate (cAMP) phosphodiesterase. Additionally, it exhibits cytotoxicity to tumor cell lines U937 and HepG2. |
In vitro | 4,5-Dimethoxycanthin-6-one demonstrates strong and uncompetitive inhibition against CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM.[2] |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 9.0 mg/mL (32.1 mM), Sonication is recommended.
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Keywords | Cytochrome P450 | CYP1A2 | CAMP PDE | cAMP | Bacterial | Antifection | 4,5-Dimethoxycanthin-6-one |
Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Doxycycline (hyclate) | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Naringin | Isoeugenol | Dimethyl sulfoxide |
Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Alkaloid Natural Product Library | Rare Natural Product Library | Selected Plant-Sourced Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |