Basic information Overview Indication Dosage and administration Plasma levels monitoring Cautions Pharmacodynamics Interactions Special populations Mode of action Psychiatric use Adverse reactions and precaution References Safety Related Supplier

ChemicalBook Product Catalog API Nervous system drugs Antiepileptic and anticonvulsant 298-46-4

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298-46-4

$ 1000.00 /1KG

Min. Order1KG
Purity99%
Cas NoCarbamazepine
Supply Ability2000kg
Update time2019-07-06

career henan chemical co

career henan chemical co

7YR

China

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Chemical Properties

Product Name	298-46-4
CAS No	Carbamazepine
EC-No	206-062-7
Min. Order	1KG
Purity	99%
Supply Ability	2000kg
Release date	2019/07/06

CR65

Carbamazepine Basic information

Product Name:	Carbamazepine
Synonyms:	Oxcarbazepine IMpurity A;CarbaMazepine (D10, 98%);CarbaMazepine (D10, 98%) 100 ug/Ml In CH3CN-D3;CarbaMazepine (D10, 98%) 100 ug/Ml In MeOH;CarbaMazepine-13C6;Carbamazepine solution ;CARBAMAZEPIN;CARBAMAZEPINE
CAS:	298-46-4
MF:	C15H12N2O
MW:	236.27
EINECS:	206-062-7
Product Categories:	Pharmaceutical raw material;TEGRETOL;Pharmaceutical;Acids and Derivatives;Heterocycles;Active Pharmaceutical Ingredients;APIs;Pharmaceutical Chemicals;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Isotope Labelled Compounds
Mol File:	298-46-4.mol

Carbamazepine Chemical Properties

Melting point	189-192 °C
Fp	9℃
storage temp.	2-8°C
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble29mg/mL
form	Crystals
color	Almost white
Water Solubility	pract. insoluble
Merck	14,1781
CAS DataBase Reference	298-46-4(CAS DataBase Reference)
NIST Chemistry Reference	Carbamazepine(298-46-4)

Safety Information

Hazard Codes	Xn,T,F
Risk Statements	42/43-22-20/21/22-39/23/24/25-23/24/25-11
Safety Statements	37-24-22-36/37/39-36-45-36/37-16
RTECS	HN8225000
HS Code	29339900
Hazardous Substances Data	298-46-4(Hazardous Substances Data)

MSDS Information

Provider	Language
Carbamazepine	English
ACROS	English

Carbamazepine Usage And Synthesis

Chemical Properties	White Solid
Uses	analgesic, anticonvulsant
Uses	Used in treatment of pain associated with trigeminal neuralgia. Anticonvulsant
Definition	ChEBI: A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
Uses	Carbamazepine (CBZ) is a first generation anticonvulsant and mood stabilizing compound that has been used as a therapeutic in the context of neuropathic pain, epilepsy, and affective disorders. It exerts its effects by blocking voltage-gated sodium channels (IC50 = 640 μM), making fewer of these channels available to subsequently open, which leads to decreased high-frequency repetitive firing of action potentials. The estimated IC50 values for inhibition of Nav1.7-, Nav1.3-, and Nav1.8-type channels by CBZ following prolonged inactivation have been reported as 406, 900, and 138 μM, respectively. CBZ can also inhibit L-type Ca2+ channels (IC50 = 974 μM) and has been shown to potentiate GABAA receptors (IC50 >3 mM).

Carbamazepine Preparation Products And Raw materials

Raw materials

2-Nitrotoluene-->Iminostilbene-->2,2'-ETHYLENEDIANILINE

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