Inhibitor Intermediates Enalapril Maleate CAS 76095-16-4 for Antihypertensive
Product Name: Enalapril maleate
Synonyms: 1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-prolin(s)-l-prolin(z)-2-bu;1-[n-[1-(ethoxycarbonyl)-3-phenylpropyl]-l-alanyl]-l-prolin(s)-l-prolin(z)-2-but;mk421maleate;Enalapril Maleate USP24,25,EP2000;Enalapril maleate BP2000/USP25;ENALAPRIL MALEATE, IMP. I (EP): 1H-IMIDAZOLE MM(CRM STANDARD);ENALAPRIL MALEATE, IMP. D (EP): ETHYL(2S)-2-[(3S,8AS)-3-METHYL-1,4-DIOXO-OCTAHYDROPYRROLO[1,2-ALPHA]PYRAZIN-2-YL]-4-PHENYLBUTANOATE MM(CRM STANDARD);ENALAPRIL MALEATE, MM(CRM STANDARD)
CAS: 76095-16-4
MF: C24H32N2O9
MW: 492.52
EINECS: 278-375-7
Enalapril maleate Chemical Properties
Melting point 143-144,5°C
Boiling point 0°C
alpha D25 -42.2° (c = 1 in methanol)
Fp 0°C
storage temp. -20°C Freezer
solubility methanol: ≥50 mg/mL, clear, colorless to yellow
form powder
pka pKa1 3.0; pKa2 (25°) 5.4
color white to off-white
Water Solubility Soluble in water, methanol, and ethanol.
Enalapril maleate Usage And Synthesis
Chemical Properties White to Off-White Crystalline Powder
Uses sunscreen
Uses An antihypertensive. An angiotensin-converting enzyme (ACE) inhibitor.
Definition ChEBI: The maleic acid salt of enalapril. It contains one molecule of maleic acid for each molecule of enalapril. Following oral administration, the ethyl ester group of enalapril is hydrolysed to afford the corresponding carboxylic acid, enalaprilat, an angioten in-converting enzyme (ACE) inhibitor. Enalapril is thus a prodrug for enalaprilat (which, unlike enalapril, is not absorbed by mouth), and its maleate is used in the treatment of hypertension and heart failure, for reduction of proteinuria and renal diseas in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients.
Advantages:
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Inhibitor Intermediates Enalapril Maleate CAS 76095-16-4 for Antihypertensive
China
