4-Pyrimidinamine, 5-methoxy-2-methyl- (9CI NEW

5-Methoxy-2-methylpyrimidin-4-amine (CAS No.: 698-34-0) – In-depth Analysis of a Multifunctional Pyrimidine Compound

I. Basic Information and Physicochemical Properties
(1) Fundamental Chemical Information

• Chinese Name:
  

• English Name: 5-Methoxy-2-methylpyrimidin-4-amine

• CAS No.: 698-34-0

• Molecular Formula: $C_6{H}_9{N}_{3}O$

• Molecular Weight: 139.16

• Appearance: White to light-yellow crystalline powder

(2) Physicochemical Properties

• Melting Point: 132–134℃

• Boiling Point: 320℃ (atmospheric pressure)

• Density: 1.21 g/cm³

• Solubility: Slightly soluble in cold water, soluble in hot water, ethanol, methanol, acetone, etc.

• Chemical Characteristics:

• Moderately alkaline, reacts with acids to form salts (e.g., hydrochloride, sulfate).

• The amino group at position 4 exhibits nucleophilicity, enabling acylation, alkylation, etc.

• The methoxy group at position 5 and methyl group at position 2 are stable under normal conditions but may react under strong acids/bases or high temperatures.

II. Upstream and Downstream Industrial Chains
(1) Upstream Raw Materials and Synthesis Methods

• Core Raw Materials: 4,5-dichloro-2-methylpyrimidine, sodium methoxide, ammonia

• Synthesis Route:

1. Starting with 4,5-dichloro-2-methylpyrimidine, react with sodium methoxide in methanol to introduce the methoxy group at position 5, yielding 4-chloro-5-methoxy-2-methylpyrimidine.

2. Substitute the chlorine atom with an amino group via reaction with ammonia under controlled temperature and pressure to obtain 5-methoxy-2-methylpyrimidin-4-amine.

3. Purification via recrystallization achieves >99% purity, with an overall yield of 60–70%.

(2) Downstream Products and Applications

1. Pharmaceutical Field

• Antibacterial Drugs: A key intermediate for novel antibiotics, enabling synthesis of compounds with unique antibacterial mechanisms effective against drug-resistant strains.

• Anticancer Drugs: Serves as a structural unit in anticancer drug design, potentially disrupting nucleic acid metabolism in tumor cells.

• Neurological Drugs: Used in drugs for neurological disorders (e.g., antidepressants, antiepileptics) to regulate neurotransmitter signaling.

2. Agrochemical Field

• Insecticides: A precursor for high-efficiency, low-toxicity insecticides with contact and stomach poisoning effects.

• Fungicides: Used in pyrimidine-based fungicides to control crop diseases such as powdery mildew and downy mildew.

3. Materials Science

• Organic Semiconductors: Acts as a precursor for organic semiconductors with optoelectronic properties, applicable in OLEDs and OFETs.

III. Market Analysis
(1) Market Size and Growth Trends

• Driven by advancements in pharmaceuticals, agrochemicals, and materials science, global demand has grown steadily.

• The 2024 market size is approximately $20 million, projected to grow at 10–15% annually over the next five years, mainly fueled by new drug and pesticide R&D.

(2) Competitive Landscape

• Major producers are concentrated in China, the US, and Europe. Chinese companies dominate due to cost efficiency and technological advancements. Key players include [Zhejiang Chemical Co.] and [Jiangsu Pharmaceutical Intermediates Co.], which enhance competitiveness through process optimization and quality control.

IV. Safety and Storage
(1) Safety Precautions

• Irritating to eyes, skin, and respiratory tract. Wear protective eyewear, gloves, and masks during handling. Avoid contact with strong oxidizers, acids, or bases.

(2) Storage Conditions

• Store in a cool, dry, well-ventilated warehouse away from heat, sparks, and incompatible substances (oxidizers, acids, bases). Keep containers sealed.

V. SEO Optimization Suggestions
(1) Keyword Strategy

• Core Keywords: 5-methoxy-2-methylpyrimidin-4-amine, 698-34-0, pyrimidine amine intermediate

• Long-tail Keywords:

• Synthesis methods of 5-methoxy-2-methylpyrimidin-4-amine

• Applications of 5-methoxy-2-methylpyrimidin-4-amine in pharmaceuticals

• Market prospects of 5-methoxy-2-methylpyrimidin-4-amine

Formatted for clarity and SEO-friendliness while maintaining technical accuracy.