| Name | 4-P-PDOT |
| Description | 4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist. |
| In vitro | In CHO-mt1 cells the amidotetraline 4-P-PDOT (10 mM) has no effect on forskolin-stimulated cyclic AMP levels, either alone, or in the presence of Melatonin. However, in CHO-MT2 cells, 4-P-PDOT is an agonist, producing a concentration-dependent inhibition of forskolin stimulated cyclic AMP, with a pEC50 value of 8.72 and intrinsic activity of 0.86[1]. |
| In vivo | 4-P-PDOT (0.5-1.0 mg/kg; intravenous injection; klotho mutant mice) treatment significantly reverses antioxidant effects mediated by Melatonin. And significantly reverses the changes in the levels of these GSH-related parameters. 4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression, Nrf2 nuclear translocation, Nrf2 DNA-binding activity, and GCL mRNA expression in the hippocampi of klotho mutant mice[2]. 4-P-PDOT treatment significantly reverses the memory function of Melatonin-treated klotho mutant mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 41.67 mg/mL (149.15 mM), Sonication is recommended.
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| Keywords | Melatonin | Melatonin Receptor | GSSG | Nrf2 | GSH | 4PPDOT | ERK | memory | damage | Inhibitor | oxidative | 4-P-PDOT | 4 P PDOT | MT2 | inhibit |
| Inhibitors Related | Agomelatine hydrochloride | N-ACETYLTRYPTAMINE | Agomelatine | Ramelteon | ACH-000143 | 2-Iodomelatonin | glycine | 6-Chloromelatonin | Tasimelteon | Melatonin | Piromelatine | Luzindole |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Antioxidant Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Human Metabolite Library |
United States
