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ChemicalBook Product Catalog 4-methoxylonchocarpin

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4-methoxylonchocarpin NEW

$195.00 1mg

$490.00 5mg

$715.00 10mg

Min. Order
Purity98%
Cas No51589-67-4
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

3YR

United States

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Chemical Properties

Product Name	4-methoxylonchocarpin
CAS No	51589-67-4
EC-No
Min. Order
Purity	98%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	4-methoxylonchocarpin
Description	4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound. 4-methoxylonchocarpin inhibited NF-κB-activated TNF expression by inhibiting the binding of LPS to TLR4 in macrophages and suppressed TNBS-induced colitis in mice.
In vitro	The roots of Abrus precatorius (AP, Fabaceae) have traditionally been used in Vietnam and China for the treatment of inflammatory diseases such as stomatitis, asthma, bronchitis, and hepatitis. In this study, we isolated 4-methoxylonchocarpin (ML). In lipopolysaccharide (LPS)-stimulated macrophages, ML was found to inhibit nuclear factor (NF)-κB activation and tumor necrosis factor (TNF) and interleukin (IL)-6 expression by inhibiting LPS binding to Toll-like receptor 4 (TLR4) in vitro.[1]
In vivo	Oral administration of 4-methoxylonchocarpin (ML) in mice with TNBS-induced colitis suppressed colon shortening and colonic myeloperoxidase activity. ML treatment significantly inhibited the activation of nuclear factor (NF)-κB and phosphorylation of transforming growth factor β-activated kinase 1 in the colon. Treatment with ML also inhibited TNBS-induced expression of IL-1β, IL-17A, and TNF. While ML reduced the TNBS-induced expression of M1 macrophage markers such as arginase-2 and TNF, it was found to increase the expression of M2 macrophage markers such as arginase-1 and IL-10. In conclusion, oral administration of ML attenuated colitis in mice by inhibiting the binding of LPS to TLR4 on immune cells and increasing the polarization of M1 macrophages to M2 macrophages.[1]
Storage	store at low temperature \| Shipping with blue ice.
Inhibitors Related	Acetylcysteine \| Diethylmaleate \| Glucosamine \| Lidocaine hydrochloride \| Apremilast \| 5-Aminosalicylic Acid \| Indole-3-carbinol \| Lenalidomide \| Diallyl disulfide
Related Compound Libraries	Flavonoid Natural Product Library \| Bioactive Compound Library \| Traditional Chinese Medicine Monomer Library \| Rare Natural Product Library \| Selected Plant-Sourced Compound Library \| Anti-Inflammatory Traditional Chinese Medicine Compound Library \| Natural Product Library for HTS \| Anti-Aging Compound Library \| Bioactive Compounds Library Max

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