1. Product information
| Product Name: | 4-Fluorobenzyl bromide |
| Synonyms: | P-FLUOROBENZYL BROMIDE;4-Fluoro-1-(bromomethyl)benzene;α-Bromo-4-fluorotoluene;4-Fluorobenzyl bromi;BroMobenzene of fluoride;Of fluoride broMide;1-(Bromomethyl)-4-fluorobenzene, alpha-Bromo-4-fluorotoluene;α-BroMo-p-fluorotoluene |
| CAS: | 459-46-1 |
| MF: | C7H6BrF |
| MW: | 189.02 |
| EINECS: | 207-291-5 |
| Product Categories: | Benzyl;Fluoro-contained benzyl bromide series;Fluorinated benzene series;alkyl bromide|alkyl Fluorine;Halogenated Heterocycles ,Pyrimidines;bc0001 |
| Mol File: | 459-46-1.mol |
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| 4-Fluorobenzyl bromide Chemical Properties |
| Boiling point | 85 °C15 mm Hg(lit.) |
| density | 1.517 g/mL at 25 °C(lit.) |
| refractive index | n20/D 1.547(lit.) |
| Fp | >230 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Chloroform |
| form | Liquid |
| Specific Gravity | 1.517 |
| color | Clear colorless to yellow |
| Sensitive | Lachrymatory |
| 4-Fluorobenzyl bromide Usage And Synthesis |
| Chemical Properties | 4-Fluorobenzyl bromide (C7H6BrF, CAS registry No. 459-46-1) is a colorless to light yellow liquid. Its flash point is 74.8 oC. It is stable at room temperature in closed containers under normal storage and handling conditions. 1,3-Difluorobenzene can react with water to form toxic fumes. Therefore, it should be stored in a tightly closed container and should be stored in a cool, dry and well-ventilated area away from incompatible substances. |
| Uses | 4-Fluorobenzyl bromide is an important intermediate in organic chemistry. 4-Fluorobenzyl bromide can be used as alkylating reagent to participate in the alkylation reaction with sulfamic esters (R-O-SO2-NH2) in liquid-liquid phase transfer conditions, resulting in the preparation of the N-dialkyled products or the corresponding ethers by scission of the O-SO2 bond, depending on the nature of R.
4-Fluorobenzyl bromide can be used for the synthesis of glycyrrhetinic acid (GA) derivatives, which are slow-binding inhibitors of tyrosinase and have inhibitory effects on melanogenesis. |
| Chemical Properties | Colorless to light yellow liqui |
| Uses | 4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials. |
| Uses | 4-Fluorobenzyl bromide was used in the preparation of:
3-acetyl-1-(4-fluorobenzyl)-4-hydroxy-1H-indole 1-(4-fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isatin (S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)pyrrolidine-1-sulfonyl)isatin 8-bromo 9-(4-fluorobenzyl) adenine 8-bromo 3-(4-fluorobenzyl) adenine
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2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
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