Application:
4-amino-2-fluorophenol can be used as an intermediate in pharmaceutical chemistry and organic synthesis. In the organic synthesis transformation, the phenolic hydroxyl group and amino group in the structure can react with alkyl halides to obtain corresponding alkylation products, which can be used in the synthesis of disinfectants, epoxy resins and preservatives.
Preparation:
Add tin (1.65 g, 14 mmol) and the corresponding phenol precursor compound (10 mmol) to a 100 ml round-bottomed flask, add a stirring rod and a reflux condenser to the system, and then add water (24 ml) to the reaction mixture, followed by concentrated hydrochloric acid (9 ml). After the reaction, the reaction mixture was cooled, and then 5M sodium hydroxide solution (20mL) was added to the reaction mixture, and the aqueous phase was extracted with ethyl acetate (3x50cm3). The organic extract was washed with saturated sodium bicarbonate aqueous solution and salt water. The organic layer was dried with MgSO4. The target product 4-amino-2-fluorophenol can be obtained by removing the solid magnesium sulfate through filtration and concentrating the organic layer until dry.
| Melting Point | 170-172°C
|
| Boiling Point | 263.3±25.0 °C
|
| Density | 1.347±0.06 g/cm3
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| Storage Condition | Amber Vial, Refrigerator, Under Inert Atmosphere
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| Solubility | Soluble in dimethyl sulfoxide and methanol
|
| pKa | 8.97±0.18
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Company Introduction
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!
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FAQ
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Express: FedEx, UPS, EMS, DHL, USPS, TNT, DPD, Aramex etc
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The company name and other contents related to pharmacy are not written on the package slips.
The way of packing is regularly changed for a secure delivery.
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Yes we can ship to USA/UK/Canada/Australia/Germany etc warehouse first then to you.
Do you ensure your packing , what about customs, what happens if the package is retained?
We concern a lot about our safety system, we pack the orders as secure as possible. If a package is seized at customs, reships of seized orders will be done provided you have a copy of the letter to show us. If you receive a seizure letter, please contact us immediately with a scanned copy of the seizure letter, and also a new address to have your order reshipped to.
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