Product Name | 4,4'-Diaminodiphenylsulfone |
CAS No. | 80-08-0 |
EINECS | 201-248-4 |
Molecular Formula | C12H12N2O2S |
Molecular Weight | 248.3 |
Appearance | White Crystalline Powder |
Dapsone (4,4 -sulfonylbisbenzeneamine; 4,4 -sulfonyldianiline;p,p -diaminodiphenylsulfone;
or DDS [Avlosulfon])occurs as an odorless, white crystalline powder that is veryslightly soluble
in water and sparingly soluble in alcohol.The pure compound is light stable, but traces of impurities,including water, make it photosensitive and thus susceptibleto discoloration in light.
Although no chemical change is detectablefollowing discoloration, the drug should be protectedfrom
light. Dapsone is used in the treatment of both lepromatous andtuberculoid types of leprosy.
Dapsone is used widely for allforms of leprosy, often in combination with clofazimine andrifampin.
Initial treatment often includes rifampin with dapsone,followed by dapsone alone. It is also used to preventthe occurrence of multibacillary leprosy when given prophylactically.Dapsone is also the
drug of choice for dermatitis herpetiformisand is sometimes used with pyrimethamine for treatment
of malaria and with trimethoprim
Serious side effects can include hemolytic anemia,methemoglobinemia, and toxic hepatic effects. Hemolyticeffects can be pronounced in patients with glucose-6-phosphatedehydrogenase deficiency. During therapy, all patientsrequire frequent blood counts.
Dapsone is approved for the treatment of an autoimmune blistering skin disease, dermatitis herpetiformis. This intensely pruritic eruption is characterized histologically by a dense dermal infiltration of neutrophils and subepidermal blisters. Other skin diseases in which dapsone is helpful are linear immunoglobulin A (IgA) dermatosis, subcorneal pustular dermatosis, leukocytoclastic vasculitis, and a variety of rarer eruptions in which neutrophils predominate, including some forms of cutaneous lupus erythematosus.
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