Product Description
Cyproheptadine hydrochloride
CAS No.: 41354-29-4
EINECS No.: 213-535-1
Molecular Formula: C21H22ClN
Molecular Weight: 323.86
Melting point: 165 °C (dec.)(lit.)
Appearance: white to light yellow crystalline powder
Standard: Enterprise Standard
Product Name Cyproheptadine Hydrochloride
CAS 41354-29-4
Appearance White Crystalline powder
Specification 99%
Test method HPLC/UV
Cyproheptadine is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.
Cyproheptadine is used to treat allergic reactions (specificallyhay fever).
Has shown effectiveness in the treatment of nightmares including nightmares related to post traumatic stress disorder.
Introduction:
Sr.No
|
TEST
|
OBSERVATION
|
SPECIFICATION
|
01.
|
APPEARANCE
|
A White
cryatalline powder
|
A white or slightly yellow,odorlessor practicallyodorless,crystalline powder.
|
02.
|
SOLUBILITY
|
Complies
|
Slightly soluble in water,freely soluble in
methanol,soluble in chloroform sparingly in
alcohol;practically in oluble in elher
|
03.
|
IDENTIFICATION
Ir Identification
(By K Br disc)
|
Complies
|
The IR spectrum of the preparation of test
specimen cxhibits maxima only at the same
wavelengths as that of similar preparation of
the corresponding Cyprol cptadine Hcl
reference standard
|
|
B.ULTRAVIOLET
ABOSORPTION
(Calculated on dried basis,%16 ug per ml in alcohol)
|
Complies
|
|
|
C.COLOR TEST
|
Complies
|
A Blue florescence is observed
|
04.
|
ACIDITY(0.05% as HCL,ml)
|
0.13ml
|
Not more than 0.15ml
|
05.
|
|
|
|
06.
|
RESIDUE ON IGNITION
(in % w/w)
|
0.06%
|
|
07.
|
HEAVY METALS(%,w/w)
|
<0.003%
|
Not more than <0.003%
|
08.
|
ADDTTIONAL TEST
Methanol
Isopropyl Alcohol
Tolucnc
Chloroform
|
45ppm
102ppm
12ppm
4ppm
|
NMT 3000 ppm
NMT 5000 ppm
NMT 890 ppm
NMT 60 ppm
|
09.
|
ASSAY(By titrimetry,on dried
basis,% w/w)
|
99.6%
|
Not less than 98.5% and Not more than 100.5%
|
Function
1. Cure urticaria, skin itch,allergic dermatitis
2. Cure acromegaly
3. Cure coryza,hemicrania
4. Cure contact dermatitis
Application
Widely used in pharmaceutical
Has been used in the management of moderate to severe cases of serotonin syndrome (a complex of symptoms associated with the use of serotonergic drugs, such as selective serotonin reuptake inhibitors and monoamine oxidase inhibitors), and in cases of hyperserotoninaemia resulting from a serotonin producing carcinoid tumour
Can also be used as a preventive measure against migraine in children and adolescents.
Can relieve SSRI-induced sexual dysfunction and drug-induced hyperhidrosis (excessive sweating).
Also used in the treatment of cyclical vomiting syndrome and to stimulate the appetite.
Advantages:
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Cyproheptadine hydrochloride 41354-29-4 Pharmaceutical Raw Materials
Cyproheptadine hydrochloride 41354-29-4 Pharmaceutical Intermediate
Cyproheptadine hydrochloride 41354-29-4 Raw Chemical Product
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