Articaine 23964-58-1

Articaine Description: 
 

Product Name

 
Articaine
 

Synonyms

 
methyl 4-methyl-3-(2propylaminopropanoylamino)
thiophene-2-carboxylate;ARTICAINE;ARTICAINE HCL;Carticaine;40045;4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester;4-Methyl-3-[1-oxo-2
(propylamino)propylamino]-2-thiophenecarboxylic acid methyl ester
 

CAS

 
23964-58-1
 

MF

 
C13H20N2O3S
 

MW

 
284.38
 

Usage

 
Articaine is an amide based short-acting local anesthetic use for regional anaesthesia in day-case settings such arthroscopy, hand , food surgery and in dentistry.
 

Articaine  Description :

1. Articaine is a local anaesthetic that has been approved overseas for several years. Like other amide anaesthetics, articaine blocks nerve conduction when it is infiltrated around a nerve. This action is prolonged by combining the drug with a vasoconstrictor
 
2. The combination of articaine can be used for local or regional anaesthesia for dental procedures. Anaesthesia begins within six minutes and lasts for an hour. The half-life of articaine is approximately 1.8 hours. It is metabolised and then mainly excreted in the urine.

3. Articaine is used for pain control. Like other local anesthetic drugs, articaine causes a transient and completely reversible state of anesthesia (loss of sensation) during (dental) procedures.
 
4. In dentistry, articaine is used both for infiltration and block injections, with the block technique yielding the greatest duration of anesthesia
 
5. Articaine is an intermediate-potency, short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. It is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or regional nerve block, or when injected intravenously for regional anesthesia
 
6. In comparative trials, its clinical effects were not generally significantly different from those of other short-acting local anesthetics like lidocaine, prilocaine, and chloroprocaine, and there is no conclusive evidence demonstrating above-average neurotoxicity.
 
7. Articaine proved to be suitable and safe for procedures requiring a short duration of action in which a fast onset of anesthesia is desired, eg, dental procedures and ambulatory spinal anesthesia, in normal and in special populations

COA:
 

Items 

Specification 

Result 

Description 

A white or almost white crystalline powder 

white crystalline powder 

Solubility 

Freely soluble in water and in alcohol

complies

Identification 

A,B,C,D

complies

PH

4.2~5.2

4.90

Appearance 
of solution

complies

Solution should be clear

complies

Related 
substances 

Impurity A <0.2%;Any other
Impurity <0.1%;Total of other
Impurities<0.5%

 
Not detected ;0.08%;0.26%

Heavy metals

<5ppm

<5ppm

Loss on drying

<0.5%

0.09%

Resiue on ignition

<0.1%

0.09%

Organic residues

complies

Assay 

98.5%~101.05

99.6%

Conclusion 

complies

 
Articaine Usage:
 
Articaine is used for pain control. Like other local anesthetic drugs, articaine causes a transient and completely reversible state of anesthesia (loss of sensation) during (dental) procedures.
 
In dentistry, articaine is used mainly for infiltration injections. Articaine, while not proven, has been associated with higher risk of nerve damage when used as a block technique. However, the ability for articaine to penetrate dense cortical bone - as found in the lower jaw (mandible) - more than most other local anaesthetics, negates the need to perform nerve blocks.
 
In people with hypokalemic sensory overstimulation, lidocaine is not very effective, but articaine works well.

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