Heparin sodium

Heparin Sodium is white or kind of white powder, odorless, has led to wet, soluble in water, insoluble in ethanol, acetone and other organic solvents.In aqueous solution, have a strong negative charge, can combine with some cation into molecular complex.A stable aqueous solution at pH 7., has the water absorbability.Anticoagulants physical and chemical properties of the molecular structure of heparin sodium heparin and low molecular heparin sodium drug interaction considerations heparin calcium heparin sodium reagent grade price

Formula: (C12H16NS2Na3) 20
Molecular weight: ca. 12000
EINECS no. : 232-681-7
Solubility: H2O: 50 mg/ml clear, faintly yellow
Form: crystalline (fine)
Color: white,
Merck: 14465 3
Stability: Stable. Incompatible with strong oxidizing agents, strong outside.
Than the curl: not less than 50 ° +
Ph: 5.5-8 .0
Protein: 0.5% or less
Dry weight loss: 5.0% or less
On ignition residue: 28.0 to 41.1%
Avoiding titer: 222 IU/mg
Wet product potency: 237 IU/mg
Packing: packed in aluminum drum
The physical and chemical properties: heparin sodium is white or kind of white powder, odorless, has led to wet, soluble in water, insoluble in ethanol, acetone and other organic solvents.in
In aqueous solution, have a strong negative charge, can combine with some cation into molecular complex.A stable aqueous solution at pH 7.

Heparin as anticoagulant drugs, it is a sticky polysaccharide substance, by extracted from the intestinal mucosa of pigs of glucosamine sulfate sodium salt, is secreted by the mast cells in human body and natural is present in the blood.Heparin sodium preventing platelet aggregation and destruction, inhibit fibrinogen to fibrin monomer, inhibit blood coagulation live element formation and confrontation of blood coagulation has been formed to live, blocking prothrombin into thrombin and antithrombin etc.

Heparin sodium in the body in vitro could delay or prevent blood clots.Its mechanism is very complex, on all affect the many steps in the process of blood coagulation.Its role as follows: (1) inhibit blood coagulation kinase of form and function, and thus hamper prothrombin into thrombin.(2) in relatively high concentrations of fashion has the inhibition of thrombin and other coagulation factors, the effect of preventing fibrinogen to fibrin;(3) can prevent platelet agglutination and destruction, etc.In addition, the anticoagulant effect of heparin sodium is its molecules associated with negative charge in the sulfuric acid root, has a positive charge, alkaline substances such as protamine or toluidine blue can neutralize the negative charges, so can inhibit its anticoagulant effect.Because of heparin in the body can activation and release of lipoprotein lipase, chyle particles of triglyceride and low density lipoprotein hydrolysis, so still have fall hematic fat action.

Heparin sodium can be used in the treatment of acute thromboembolic disease, diffuse intravascular coagulation (DIC).In recent years found that liver known as the removal of blood lipid.Deep intravenous or intramuscular injection or hypodermic, each unit of 5000 ~ 10000.Heparin of low toxicity, spontaneous bleeding tendency is the most main risk excessive use of heparin.Oral invalid and must be injected.Intramuscular injection or hypodermic stimulus is bigger, I can produce allergic reaction, even more than quantity can make cardiac arrest;I see a sex hair loss and diarrhea.In addition, the fair cause spontaneous fractures.Use for a long time sometimes can form thrombus, may be the consequences of anticoagulant enzyme - depletion.Has a tendency to bleeding, severe liver, renal insufficiency, severe hypertension, hemophilia, intracranial hemorrhage, peptic ulcer, pregnancy and postpartum, visceral tumors, trauma, and surgery are disabled heparin sodium.

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