| 名称 | 3,5,6,7,8,3',4'-Heptemthoxyflavone |
| 描述 | 3,5,6,7,8,3',4'-Heptemthoxyflavone exhibits neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging, and photoprotective effects; it inhibits collagenase activity, induces type I procollagen synthesis in HDFn cells, and combats nitric oxide (NO) carcinogenesis. |
| 体外活性 | 3,5,6,7,8,3',4'-Heptamethoxyflavone (HMF), extracted from C. unshiu peels using ethanol extraction and hexane fractionation, inhibited collagenase activity and increased type I procollagen content in UV-induced human dermal fibroblast neonatal (HDFn) cells. HMF also suppressed matrix metalloproteinases 1 (MMP-1) expression and induced type I procollagen protein expression in these cells. Additionally, HMF inhibited UVB-induced phosphorylation of MAPK cascade signaling components—ERK, JNK, and c-Jun—thereby reducing MMP-1 expression. Furthermore, HMF modulated the TGF-β/Smad signaling pathway by inducing Smad3 and suppressing Smad7 protein expressions in a dose-dependent manner in UV-induced HDFn cells. |
| 存储条件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 12 mg/mL (27.75 mM)
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| 关键字 | inhibit | 3,5,6,7,8,3',4'-Heptemthoxyflavone | Inhibitor | 3,?5,?6,?7,?8,?3',?4'-?Heptemthoxyflavone | 3,5,6,7,8,3',4' Heptemthoxyflavone | 3,5,6,7,8,3',4'Heptemthoxyflavone |
| 相关库 | 中药单体化合物库 | 经典已知活性库 | 植物来源化合物库 | 天然产物库 | 中药抗炎分子库 | 神经保护化合物库 | 高通量筛选天然产物库 | 抗癌活性化合物库 | 药食同源库 |
United States
