| CAS: | 300-39-0 |
| MF: | C9H9I2NO3 |
| MW: | 432.98 |
| EINECS: | 206-092-0 |
| Product Categories: | Pharmaceutical Raw Materials;Amino Acids;Unusual Amino Acids;Biochemistry;Biological-modified Amino Acids |
| Mol File: | 300-39-0.mol |
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| 3,5-Diiodo-L-tyrosine dihydrate Chemical Properties |
| Melting point | 200 °C (dec.)(lit.) |
| alpha | -20.7 º (c=2.5, 0.1N NaOH/H2O) |
| Boiling point | 546.5°C (rough estimate) |
| density | 2.405±0.06 g/cm3(Predicted) |
| refractive index | 1.2 ° (C=5, 1mol/L HCl) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly), DMSO (Slightly) |
| pka | 2.12(at 25℃) |
| form | crystalline |
| color | white |
| Water Solubility | slightly soluble |
| Sensitive | Light Sensitive |
| CAS DataBase Reference | 300-39-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 3,5-Diiodo-l-tyrosine(300-39-0) |
| EPA Substance Registry System | L-Tyrosine, 3,5-diiodo- (300-39-0) |
| 3,5-Diiodo-L-tyrosine dihydrate Usage And Synthesis |
| Description | Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid gland activity. |
| Chemical Properties | white to beige powder |
| Uses | It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters, and other illnesses accompanied by thyrotoxicity. |
| Uses | 3,5-Diiodo-L-tyrosine is a reactant used in the synthesis of fluorescent unnatural amino acids bearing stilbene or vinylene backbones. Also used in the discovery of potent heterodimeric antagonists of inhibitor of Apoptosis proteins with prolonged anti-tumor activity. |
| Uses | 3,5-Diiodo-L-tyrosine Dihydrate is a thyroid hormone receptor agonist. |
| Definition | ChEBI: A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis. |
| Synthesis | Diiodotyrosine, 3,5-diiodotyrosine (25.2.1), is synthesized by directly iodinating tyrosine with iodine in the presence of sodium iodide in aqueous ethylamine, or in a mixture of acetic and hydrochloric acids with the addition of hydrogen peroxide. 
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| Purification Methods | It forms crystals from H2O [solubility (g/L): 0.204 at 0o, 1.86 at 50o, 5.6 at 75o and 17.0 at 100o]. Also recrystallise it from 50% or 70% EtOH. When boiled in EtOH the crystals swell, and on further boiling a gelatinous precipitate is formed [Harrington Biochem J 22 1434 1928, Jurd J Am Chem Soc 77 5747 1955]. It also crystallises from cold dilute ammonia on adding acetic acid to pH 6. [Beilstein 14 IV 2370.] |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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