Name | 3,4-O-Isopropylidene-shikimic acid |
Description | 3,4-O-Isopropylidene-shikimic acid (3,4-O-Isopropylidene shikimic acid) exhibits significant anti-inflammatory, anti-thrombosis, antioxidant, and analgesic effects, and provides protective benefits against trinitrobenzenesulfonic acid-induced experimental colitis in rats, likely because of its antioxidant properties. |
In vitro | 3,4-O-Isopropylidene shikimic acid (ISA,1-100 micromol/L) effectively reduced PMN adhesion to TNF-alpha-induced HUVEC with the inhibitory rate from 17.2 % to 53.5 % and exerted no effect on PMN adhesion to normal HUVEC. Adhesion molecule ICAM-1 surface protein and mRNA expression induced by TNF-alpha (400 kU/L) were significantly inhibited by ISA. In addition, the cell viability of HUVEC was unchanged 48 h after treatment with ISA[1] |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 60 mg/mL (280.09 mM)
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Keywords | anti-inflammatory | acid | 3,4 O Isopropylidene shikimic acid | antioxidant | 3,4-O-Isopropylidene-shikimic acid | 3,4OIsopropylideneshikimic acid | Inhibitor | inhibit | shikimic |
Inhibitors Related | Aminoguanidine hydrochloride | L-NAME hydrochloride | Mifepristone | 2,4-Diamino-6-hydroxypyrimidine | Dexamethasone acetate | S-Methylisothiourea sulfate | L-Arginine | Nitroarginine | Ethyl cinnamate | Methylene Blue trihydrate | Diallyl disulfide | L-Arginine hydrochloride |
Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Neuroprotective Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Bioactive Compounds Library Max |