Product name: 3-N-Boc-aminocyclohexanone
CAS Number: 885280-38-6
Molecular Weight: 213.27
Molecular Formula:C11H19NO3
Chemical & Physical Properties
Melting Point | 80-85℃ |
Boiling Point | 335.9±31.0℃（Predicted) |
Density | 1.06±0.1g/cm3(Predicted) |
Storage cinditions | Keep in dark place,Sealed in dry,Store in freezer,under -20℃ |
Solubility | Soluble in chloroform(a little),methanol(a little) |
Acidity coefficient(pKa) | 12.01±0.20（Predicted) |
morphology | Solid
|
color | Light beige
|
Uses and preparation of 3-N-Boc-aminocyclohexanone:
N-BOC-3-cyclohexanone amine is an organic intermediate that has been reported in the literature to be used in the preparation of BTK inhibitors.
The solution of 2-cyclohexen-1-one (14 ml, 150 mmol) and tert-butyl carbamate (17 g, 145.11 mmol) in DCM (30 ml) is stirred with bismuth nitrate pentahydrate (14 g, 28.8 mmol) for 21 h at room temperature. It was further diluted with DCM, filtered with hyflo, the filtrate was washed with sodium bicarbonate solution and saline, the organic phase was dried with Na2SO4, and the solvent was filtered and evaporated to obtain a crude product of 22.1 g. Silica gel chromatography (EtOAc/cyclohexanol 3:7) followed by crystallization from the same solvent system yielded N-BOC-3-cyclohexanone amine (14.43 g, 47%).
First Aid Measures:
Inhalation: If inhaled, move the patient to fresh air.
Skin-to-skin contact: Remove contaminated clothing and rinse skin thoroughly with soap and water. If you feel unwell, seek medical attention.
Ocular contact: Separate eyelids and rinse with running water or saline. Seek immediate medical attention.
Ingestion: Rinse your mouth, prohibit vomiting. Seek immediate medical attention.
Advice for protecting rescuers: Move the patient to a safe place. Consult a doctor. Present this SDS to the doctor who is present at the scene.
Special note for doctors: No data
Emergency response to leakage:
1. Protective measures, protective equipment and emergency handling procedures for operators:
Emergency responders are advised to wear air-carrying respirators, anti-static clothing, and rubber oil-resistant gloves.
Do not touch or cross the spill.
All equipment used for the job should be grounded.
Cut off the source of the leak as much as possible. Eliminate all ignition sources.
The warning area is demarcated according to the influence area of liquid flow, steam or dust diffusion, and unrelated personnel are evacuated to the safety zone from the crosswind and upwind direction.
2. Environmental protection measures: Contain leaks to avoid polluting the environment. Prevent spills from entering sewers, surface water, and groundwater.
3. Methods of containment and removal of spilled chemicals and disposal materials used:
Small leaks: Collect the leaked liquid in a sealable container whenever possible. Absorb with sand, activated carbon or other inert materials and move to a safe place. It is forbidden to flush down the drain.
Massive leakage: Construct embankments or dig pits to contain them. Close the drain pipes. Cover with foam to inhibit evaporation. The explosion-proof pump is transferred to a tanker or a special collector for recycling or transported to a waste disposal site for disposal.
China
