- 3α-hydroxy-6-ethyl-7-keto-5β-cholan-24-oic acid is a chemical compound with the molecular formula C26H42O4 and the molecular weight 418.62 g/mol .
- It is a white solid that is soluble in dichloromethane, chloroform, ethyl acetate, DMSO and methanol .
- It has a boiling point of 561.5±25.0 °C and a pKa of 4.76±0.10 .
- It is an intermediate used in the synthesis of 6α-ethyl ursodeoxycholic acid, which is an epimer of obeticholic acid .
- Obeticholic acid is a derivative of the bile acid chenodeoxycholic acid and a potent activator of the farnesoid X nuclear receptor, which reduces liver fat and fibrosis in animal models of fatty liver disease .
- Obeticholic acid is also used to treat primary biliary cholangitis, a chronic liver disease caused by autoimmune destruction of the bile ducts .
Email: pharmchem1@ichemie.com
Tel&Whatsapp:+86-18771921569