1. Materials information
Names
| Name |
3-Chloro-5-hydroxybenzoic acid
|
| Synonym |
More Synonyms
|
3-Chloro-5-hydroxybenzoic acid Biological Activity
| Description |
3-Chloro-5-hydroxybenzoic acid is a potent, orally active and
selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for
human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo
effects on lipolysis in a mouse model of obesity[1]. |
| Related Catalog |
Signaling Pathways >>
Others >>
Others
Research Areas >>
Metabolic Disease
|
| In Vitro |
3-Chloro-5-hydroxybenzoic acid shows potency against human
(EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM),
mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM)[1].
|
| In Vivo |
3-Chloro-5-hydroxybenzoic acid (30, 100, and 300 mg/kg; PO in
overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks) shows
significant reductions in free fatty acids at all doses tested,
resulting in a minimum efficacious dose of 30 mg/kg[1]. Pharmacokinetic
Parameters of 3-Chloro-5-hydroxybenzoic acid in Mice[1]. dose (mg/kg)
tmax (h) AUCinf (h ng/mL) Cmax (ng/mL) Cmax (μM) t1/2 (h) 30 0.5 9356
11689.50 67.2 1.47 100 0.5 51312 55252.80 341.9 1.10 Animal Model:
C57Bl6/J mice (DIO mice)[1] Dosage: 30, 100, and 300 mg/kg
Administration: PO in overnight fasted C57Bl6/J mice fed high fat chow
for 10 weeks Result: Significant reductions in nonesterified free fatty
acid cholesterol (NEFAc) at all doses tested.
|
| References |
[1]. Dvorak
CA, et al. Identification of Hydroxybenzoic Acids as Selective Lactate
Receptor (GPR81) Agonists with Antilipolytic Effects. ACS Med Chem Lett.
2012;3(8):637-639. Published 2012 Jun 11.
|
Chemical & Physical Properties
| Density |
1.5±0.1 g/cm3 |
| Boiling Point |
364.8±27.0 °C at 760 mmHg |
| Molecular Formula |
C7H5ClO3 |
| Molecular Weight |
172.566 |
| Flash Point |
174.4±23.7 °C |
| Exact Mass |
171.992722 |
| PSA |
57.53000 |
| LogP |
2.83 |
| Vapour Pressure |
0.0±0.9 mmHg at 25°C |
| Index of Refraction |
1.630 |
MSDS
|
3-Chloro-5-hydroxybenzoic acid MSDS(Chinese)
|
Safety Information
| Symbol |
GHS05, GHS07
|
| Signal Word |
Danger |
| Hazard Statements |
H302-H315-H318-H335
|
| Precautionary Statements |
P261-P280-P305 + P351 + P338
|
| RIDADR |
NONH for all modes of transport |
| HS Code |
2918290000 |
Customs
| HS Code |
2918290000 |
| Summary |
HS: 2918290000 other carboxylic acids with phenol function but
without other oxygen function, their anhydrides, halides, peroxides,
peroxyacids and their derivatives Tax rebate rate:9.0% Supervision
conditions:AB(certificate of inspection for goods inward,certificate of
inspection for goods outward) VAT:17.0% MFN tariff:6.5% General
tariff:30.0% |
2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
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CAS#:98406-04-3
