Application, Preparation Methods, Uses, and Synthesis Methods of 3-Bromo-6-Chloropyridazine MSDS3-Bromo-6-Chloropyridazine Price (Reagent Grade) Upstream and Downstream Product Information Topic Chinese Name: 3-Bromo-6-Chloropyridazine Chinese Synonyms: 3-Bromo-6-Chloropyridazine English Name: 3-BROMO-6-CHROPYRIDAZINE English Synonyms: 3-BROMO-6-CHROPYRIDAZINE; 3-Brom-6-chlorpyridazin; 3-bromanyl-6-chloranyl-pyridazine; Pyridazine,3-bromo-6-chloro; 3-BROMO-6-CHLOROPYRIDAZINEISO9001:2015REACHCAS No.: 89089-18-9 Molecular formula: C4H2BrClN2 Molecular weight: 193.43EINECS No.: 200-001-2 Related category: Intermediates - Organic Intermediates; Pyridazine Mol File: 89089-18-9. mol 3-Bromo-6-chloropyridazine Properties Melting point 93.5-94 ° C (Solv: ligroine (8032-32-4) Boiling point 300.8 ± 22.0 ° C (Predicted) Density 1.859 ± 0.06g/cm3 (Predicted) Storage conditions Undernertgas (nitroorArgon) at 2-8 ° C Acidity coefficient (pKa) -1.48 ± 0.10 (Predicted) 3-Bromo-6-chloropyridazine Uses and synthesis methods Application 3-Bromo-6-chloropyridazine is an organic intermediate that can be synthesized from 3-amino acids 6-chloropyridazine was obtained by bromination after diazotization. Preparation method: Add sodium nitrite (4.18 g, 60.7 mmol) in water (6 mL) to a 48% HBr solution of 3-amino-6-chloropyridazine (3.0 g, 23.3 mmol) at - 10 ℃. Slowly add bromine (11.2 g, 3eq) and stir the reaction at room temperature for 48 hours. After adding a solution of NaOH (16.8g) in water (42mL) and extracting with Et2O, the organic layer is dried and evaporated through Na2SO4. After purification by rapid chromatography using DCM/cyclohexane 50/50 as an eluent, the title compound was obtained in a yield of 44% as a white solid.