Name | 2,5-Dihydroxyacetophenone |
Description | 1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs, it also can potentiate the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells. 3. 2,5-Dihydroxyacetophenone (Quinacetophenone) has anti-inflammatory activity in activated macrophages, raising the possibility that this compound has a therapeutic potential for inflammatory conditions. 4. 2,5-Dihydroxyacetophenone (Quinacetophenone) is an uncompetitive inhibitor of murine tyrosinase (K(I) 0.28mm), it strongly inhibits both melanogenesis and cellular tyrosinase activity in vitro in 3-isobutyl-1-methylxanthin-stimulated B16 mouse melanoma cells or in vivo in zebrafish and mouse models. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 45 mg/mL (295.76 mM), Sonication is recommended. Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc. : Soluble
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Keywords | p65 | Rehmanniae | Preparata | mediators | mRNA | NF-κB | iNOS | 2,5 Dihydroxyacetophenone | Inhibitor | Nuclear factor-kappaB | Nuclear factor-κB | Extracellular signal regulated kinases | inflammatory | 2,5Dihydroxyacetophenone | ERK | Radix | TNF-α | IL-6 | 2,5-Dihydroxyacetophenone | RAW264.7 | LPS-stimulated | inhibit | macrophages |
Inhibitors Related | TBHQ | Diethylmaleate | Glucosamine | Oxyresveratrol | Lidocaine hydrochloride | Methyl cinnamate | 5-Aminosalicylic Acid | Indole-3-carbinol | Diallyl disulfide |
Related Compound Libraries | Pain-Related Compound Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Inhibitor Library | Neuroprotective Compound Library | Natural Product Library for HTS | Cosmetic Ingredient Compound Library | Food as Medicine Compound Library |