| Name | 2,5-Dihydroxyacetophenone |
| Description | 1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs, it also can potentiate the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells. 3. 2,5-Dihydroxyacetophenone (Quinacetophenone) has anti-inflammatory activity in activated macrophages, raising the possibility that this compound has a therapeutic potential for inflammatory conditions. 4. 2,5-Dihydroxyacetophenone (Quinacetophenone) is an uncompetitive inhibitor of murine tyrosinase (K(I) 0.28mm), it strongly inhibits both melanogenesis and cellular tyrosinase activity in vitro in 3-isobutyl-1-methylxanthin-stimulated B16 mouse melanoma cells or in vivo in zebrafish and mouse models. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45 mg/mL (295.76 mM), Sonication is recommended. Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc. : Soluble 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (13.14 mM), Sonication is recommended.
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| Keywords | Tyrosinase | TNF-α | Rehmanniae | RAW264.7 | Radix | Preparata | p65 | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | NFκB | NF-kB | NFkB | mRNA | mediators | macrophages | LPS-stimulated | iNOS | Inhibitor | inhibit | inflammatory | IL-6 | Extracellular signal regulated kinases | ERK | 2,5-Dihydroxyacetophenone | 2,5Dihydroxyacetophenone | 2,5 Dihydroxyacetophenone |
| Inhibitors Related | Urea | Sodium propionate | Kojic acid | Gum arabic | Fumaric acid | 1,4-Naphthoquinone | Ethyl linoleate | D-Psicose | Oxyresveratrol | 2-Ketoglutaric acid | N,N-Dimethylacetamide | Gluconate Calcium |
| Related Compound Libraries | Polyphenolic Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Inhibitor Library | Tobacco Monomer Library | Neuroprotective Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Food as Medicine Compound Library |