| Making | Dissolve pyrimidine dichloride in anhydrous methanol, add it to anhydrous sodium methoxide solution under stirring, reflow for 45 min, cool down, filter to remove sodium chloride, evaporate the filtrate under normal pressure to remove methanol, dissolve the residue in 30% sodium hydroxide in Chemicalbook, and extract it with ether. After the ether extract is washed with water and dehydrated with anhydrous sodium sulfate, the ether is evaporated, and the fraction at 196-210 ℃ is collected to obtain 2,4-dimethoxypyrimidine in a yield of 83-88% |
China
