Name | 2',4'-DIHYDROXYCHALCONE |
Description | 2',4'-DIHYDROXYCHALCONE (2',4'-DHC) as a compound with Hsp90 inhibitory and antifungal effects |
In vitro | In the presence of 2',4'-DHC (8 g/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked.?The expression of the conidiation-associated genes abaA, brlA, and wetA was significantly decreased (approximately 3- to 5-fold) by treatment with 2',4'-DHC.?The expression of calcineurin signaling components, cnaA and crzA, was also significantly reduced.?The inhibitory effects of 2',4'-DHC on metabolic activity and mycelial growth were significantly enhanced by combination treatment with itraconazole and caspofungin.?Docking studies indicated that 2',4'-DHC bind to the ATPase domain of Hsp90.?2',4'-DHC act as an Hsp90-calcinurin pathway inhibitor[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 11 mg/mL (45.78 mM)
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Keywords | 2',4'DIHYDROXYCHALCONE | 2',4' DIHYDROXYCHALCONE | 2',4'-DIHYDROXYCHALCONE |
Inhibitors Related | Ethoxyquin | SNX0723 | Tamoxifen | SNX2112 | Teprenone | Elesclomol | Rifabutin | Palmitic acid | Paeoniflorin | Tamoxifen Citrate |
Related Compound Libraries | Bioactive Compound Library | Anti-Breast Cancer Compound Library | Anti-Fungal Compound Library | Inhibitor Library | NO PAINS Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Infection Compound Library | Anti-Cancer Compound Library |