Name | 2,3-Dihydroxy-4-methoxyacetophenone |
Description | 2,3-Dihydroxy-4-methoxyacetophenone (2',3'-Dihydroxy-4'-methoxyacetophenone) is a natural product,it improves cognitive function and may be helpful for the treatment of Alzheimer's disease. |
In vivo | Oral administered of 2,3-dihydroxy-4-methoxyacetophenone (1, 10, 20, 40 and 50mg/kg) to amnesic mice induced by scopolamine.?In Morris water maze test, 2,3-dihydroxy-4-methoxyacetophenone (50mg/kg) improved the impairment of spatial memory induced by scopolamine.?2,3-Dihydroxy-4-methoxyacetophenone protect HT22 cells on glutamate induced cell-death in a dose-dependent manner (EC50 value: 10.94μM).?Furthermore, 2,3-dihydroxy-4-methoxyacetophenone was found to inhibit [Ca(2+)] accumulation in HT22 cells and had antioxidantive activity.?2,3-dihydroxy-4-methoxyacetophenone exert neuroprotective and cognitive-enhancing activities through its antioxidant activity.?2,3-dihydroxy-4-methoxyacetophenone improves cognitive function and may be helpful for the treatment of Alzheimer's disease. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 22.5 mg/mL (123.51 mM)
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Keywords | inhibit | 2,3Dihydroxy4methoxyacetophenone | Inhibitor | 2,3 Dihydroxy 4 methoxyacetophenone | 2,3-Dihydroxy-4-methoxyacetophenone |
Inhibitors Related | L-Ascorbic acid | Ethyl cinnamate | 1-Octanol |
Related Compound Libraries | 疼痛相关化合物库 | 经典已知活性库 | 神经退行性疾病化合物库 | 中药单体化合物库 | 膜蛋白靶向化合物库 | 植物来源化合物库 | 天然产物库 | 神经保护化合物库 | 古代经典名方目录分子库 |