| CAS: | 522-48-5 |
| MF: | C13H17ClN2 |
| MW: | 236.74 |
| EINECS: | 208-329-3 |
| Product Categories: | VISINE;Intermediates & Fine Chemicals;Adrenergics;Agonists;Neurotransmitters;Pharmaceuticals;Pharmaceutical intermediates;Inhibitors |
| Mol File: | 522-48-5.mol |
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| 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Chemical Properties |
| Melting point | 248-251°C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: freely soluble |
| form | neat |
| color | White to Off-White |
| InChIKey | BJORNXNYWNIWEY-UHFFFAOYSA-N |
| CAS DataBase Reference | 522-48-5(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, monohydrochloride (522-48-5) |
| 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Usage And Synthesis |
| Chemical Properties | Off-White Solid |
| Originator | Tyzine,Pfizer,US,1954 |
| Uses | An alpha agonist, causing constriction of conjunctival blood vessels. Used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants. |
| Uses | adrenergic agonist, nasal decongestant |
| Uses | 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride is an alpha agonist, causing constriction of conjunctival blood vessels,it is used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants. |
| Definition | ChEBI: Tetrahydrozoline hydrochloride is the hydrochloride salt of tetryzoline. It is used as a nasal decongestant. It has a role as a sympathomimetic agent, a vasoconstrictor agent and a nasal decongestant. It contains a tetryzoline(1+). |
| Manufacturing Process | A mixture of 540 grams (9.0 mols) of ethylenediamine, 270 grams (1.53 mols) of 1,2,3,4tetrahydro-α-naphthoic acid, and 360 ml (4.32 mols) of concentrated hydrochloric acid was introduced into a two-liter, three-necked flask fitted with a thermometer, stirrer, and distillation takeoff. The mixture was distilled under a pressure of about 20 mm of mercury absolute until the temperature rose to 210°C. Thereafter, heating was continued under atmospheric pressure and when the temperature reached about 260°C, an exothermic reaction was initiated. The heat was then adjusted to maintain a reaction temperature of 275° to 280°C for 45 minutes and the mixture thereafter cooled to room temperature.
900 ml of 4 N hydrochloric acid was added and the aqueous layer stirred with warming until a clear, brown solution resulted. This brown solution was made strongly alkaline with sodium hydroxide. The oil that separated solidified and was collected on a filter leaving filtrate A. The solid was dissolved in 370 ml of alcohol with warming, and the solution was treated with 130 ml of concentrated hydrochloric acid with stirring and cooling. This acidified mixture was diluted with 300 ml of ether and chilled. The solid salt was collected and dried and the filtrate concentrated to approximately 300 ml, diluted with 300 ml of ether and the salt which separated collected and dried.
Filtrate A was extracted with ether, dried, acidified with alcoholic hydrogen chloride, and the salt which separated was collected and dried. There was thus obtained, when all the salt had been combined, 250 grams (69.3% of the theoretical yield) of 2-(1,2,3,4-tetrahydro-1-naphthyl)imidazoline hydrochloride, melting at 256° to 257°C. |
| Brand name | Tetryzo- line is INN and BAN; Tetryzoline Hydrochloride is JAN; Tetrahydrozoline Nitrate is JAN. |
| Therapeutic Function | Nasal decongestant, Pharmaceutic aid |
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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