| Name | 2-(Hydroxymethyl)anthraquinone |
| Description | 2-(Hydroxymethyl)anthraquinone exhibits strong activity against Helicobacter pylori ATCC 43504 at 0.01 mg/disc. |
| In vitro | The growth-inhibiting activity of Tabebuia impetiginosa Martius ex DC dried inner bark-derived constituents against Helicobacter pylori ATCC 43504 was examined using paper disc diffusion and minimum inhibitory concentration (MIC) bioassays. The activity of the isolated compounds was compared to that of the commercially available anti-Helicobacter pylori agents, amoxicillin, metronidazole, and tetracycline. The biologically active components of Tabebuia impetiginosa dried inner bark (taheebo) were characterized by spectroscopic analysis as 2-(Hydroxymethyl)anthraquinone, anthraquinone-2-carboxylic acid, and 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol). With the paper disc diffusion assay 2-(Hydroxymethyl)anthraquinone exhibited strong activity against Helicobacter pylori ATCC 43504 at 0.01 mg/disc. Anthraquinone-2-carboxylic acid, lapachol and metronidazole were less effective, exhibiting moderate anti-Helicobacter pylori activity at 0.1 mg/disc. Amoxicillin and tetracycline were the most potent compounds tested, displaying very strong activity at 0.005 mg/disc. 2-(Hydroxymethyl)anthraquinone exhibited moderate activity at this dose. Tetracycline still had strong activity at 0.001 mg/disc while amoxicillin had little activity at this dose. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (209.87 mM), Sonication is recommended.
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| Keywords | sex pheromone | PRPG | Photoremovable | Inhibitor | inhibit | controlled-release | Chilo infuscatellussnellen | Anti-infection | Antiinfection | Antifection | 2-(Hydroxymethyl)anthraquinone | 2(Hydroxymethyl)anthraquinone | 2 (Hydroxymethyl)anthraquinone |
| Inhibitors Related | Cefotaxime | Pyrolin | N-(Hydroxymethyl)nicotinamide | Penicillin G potassium | 3,4,5-Trimethoxybenzaldehyde | 1,3-Dithiane | Sorbic acid | A 21960 | (E)-3-(p-Tolyl)acrylaldehyde | 2-Furoic acid | α-Terpineol | 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol |
| Related Compound Libraries | Food Sourced Compound Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Chinese Pharmacopoeia Natural Product Library | Natural Product Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Ancient Chinese Classical Formulas Compound Library |
United States
