| CAS: | 14080-23-0 |
| MF: | C5H3N3 |
| MW: | 105.1 |
| EINECS: | 604-202-5 |
| Product Categories: | Heterocycle-Pyrimidine series;cyanide;Building Blocks;C4 to C5;Chemical Synthesis;Heterocyclic Building Blocks;PYRIMIDINE;APIs & Intermediate;Pyridines, Pyrimidines, Purines and Pteredines;Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Heterocyclic Building Blocks;Pyrimidines;FINE Chemical & INTERMEDIATES;bc0001 |
| Mol File: | 14080-23-0.mol |
 |
|
| 2-Cyanopyrimidine Chemical Properties |
| Melting point | 40-44 °C (lit.) |
| Boiling point | 250.7±23.0 °C(Predicted) |
| density | 1.22±0.1 g/cm3(Predicted) |
| Fp | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | -3.27±0.13(Predicted) |
| form | Crystalline Powder |
| color | White to yellow |
| InChIKey | IIHQNAXFIODVDU-UHFFFAOYSA-N |
| CAS DataBase Reference | 14080-23-0(CAS DataBase Reference) |
| 2-Cyanopyrimidine Usage And Synthesis |
| Chemical Properties | White to yellow to brown solid |
| Biological Activity | 2-cyano-pyrimidine is a cathepsin k inhibitor.cathepsin k is a protease defined by its high specificity for kinins, which is involved in bone resorption. cathepsin k's ability to catabolize collagen, elastin, and gelatin allow it to break down bone and cartilage. such catabolic activity is also partially responsible for the loss of lung elasticity and recoil in emphysema. therefore, inhibitors of cathepsin k are showing great potential in the treatment of osteoporosis. |
| in vitro | 2-cyano-pyrimidine was identified as a cathepsin k inhibitor whose basic structure and derivatives have been evaluated for the treatment of osteoporosis. enzymatic study showed that 2-cyano-pyrimidine had an ic50 value of 170 nm for inhibition of cathepsin k, elevated activity of which has been linked to the formation of osteoporosis and arthritis. moreover, cathepsin k was found to be a lysosomal cysteine protease found in osteoclasts. [1,2]. |
| IC 50 | 170 nm |
| references | [1] altmann, e. ,aichholz, r.,betschart, c., et al. 2-cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin k. journal of medicinal chemistry 50(4), 591-594 (2007).
[2] rankovic z et al. design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin k inhibitors. bioorg med chem lett. 2010 mar 1;20(5):1524-7. |
Product picture
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
Advantage
In stock
China
