| Name | 2-Bromo-4'-hydroxyacetophenone |
| Description | 2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM [1]. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research [2]. |
| Cell Research | Cell lines: human B cells. Concentrations: 30, 100, 300, 1000 μM. Method: After incubation with varying concentrations of PTP Inhibitor I for 3 min, the cells are lysed, and the cellular proteins are separated on an SDS-PAGE gel, followed by western blot analysis. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 20 mg/mL (93.01 mM), Sonication is recommended.
H2O : Insoluble
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (9.3 mM), Sonication is recommended.
DMSO : 60 mg/mL (279.02 mM), Sonication is recommended.
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| Keywords | protein tyrosine phosphatase(PTP) | Phosphatase | Inhibitor | inhibit | alpha-Bromo-4-hydroxyacetophenone | a-Bromo-4-hydroxyacetophenone | 4-Hydroxyphenacyl Bromide | 2Bromo4'hydroxyacetophenone | 2-Bromo-4'-hydroxyacetophenone | 2 Bromo 4' hydroxyacetophenone |
| Inhibitors Related | Osunprotafib | PTP1B-IN-22 | Disodium monofluorophosphate | β-Glycerophosphate disodium salt pentahydrate | Idoxuridine | Cyclosporine | Tartaric acid disodium dihydrate | Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride | CaMKP Inhibitor | L-Ascorbic acid 2-phosphate magnesium | Trimyristin | β-Glycerophosphate disodium salt hydrate |
United States
