2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine NEW

$1.00 1000KG

$50.00 1KG

Min. Order1KG
Purity99%
Cas No3605-01-4
Supply Abilityg-kg-tons, free sample is available
Update time2023-12-23

Henan Fengda Chemical Co., Ltd

2YR

China

Chemical Properties

Product Name	2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
CAS No	3605-01-4
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	g-kg-tons, free sample is available
Release date	2023/12/23

1. Product information

Product Name:	2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
Synonyms:	PIRIBEDIL;Piribendyl;2-(4-(benzo[d][1,3]dioxol-5-ylMethyl)piperazin-1-yl)pyriMidine;1-(2-Pyrimidyl)-4-piperonylpiperazine;PIRIBEDIL(FORR&DONLY0;PIRIBEDIOL;ET-495;EU-4200
CAS:	3605-01-4
MF:	C16H18N4O2
MW:	298.34
EINECS:	222-764-6
Product Categories:	Isotope labelled API;API
Mol File:	3605-01-4.mol

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Chemical Properties

Melting point	98°
Boiling point	439.76°C (rough estimate)
density	1.1183 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	7.17±0.10(Predicted)
form	Solid
color	White

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Usage And Synthesis

Chemical Properties	White Solid
Originator	Trivastal, Eutherapie ,France,1969
Uses	Piribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impai rment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.
Uses	Piribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impairment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.
Definition	ChEBI: 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine is a N-arylpiperazine.
Manufacturing Process	To a solution of 21 g of 1-(3':4'-methylenedioxybenzyl)-piperazine in solution in 300 cc of anhydrous xylene there were added 28 g of anhydrous potassium carbonate and then 11.3 g of 2-chloropyrimidine. The suspension was then heated for 9 hours at boiling point (130°C). After this time, the mixture was cooled and extracted several times with 10% hydrochloric acid. The acid solution obtained was washed with ether and then rendered alkaline with potassium carbonate; the oily product which was separated was extracted with chloroform and this, after drying with potassium carbonate and evaporation, gave an oily residue weighing 20 g. By dissolution in boiling ethanol and crystallization, 15 g of crystals melting at 96°C were recovered.
Therapeutic Function	Vasodilator