Hot Selling Estriol Powder 50-27-1 with Best Price From Biocar Lab
Product description
Usage And Synthesis
Estriol is produced through the hydroxylation of carbon 16 in dehydroepiandrosterone at fetal adrenal; it further enters into the placenta and the metabolism by the placental syncytiotrophoblast cells. It is then released into the maternal blood with the free estriol absorbed by the maternal liver and further combined into glucuronic acid or sulfuric acid estriol that are further excreted by the kidneys. Therefore, the estriol in the urine is all in the form of conjugated estriol while the estriol in the blood contains both free type and bound type with free form accounting for about 10 to 30% and the rest being in bound form. Determination of estriol in the urine of pregnant women with a spectrophotometer has been widely used clinically. There are other common methods including radioimmunoassay. Estriol is not contained in the blood of non-pregnant women. According to the measurement of the Shanghai Second Medical Ruijin Hospital, upon 26 weeks of pregnancy, the plasma free estriol is 4~6ng/ml while upon 36 weeks, it is 10~12ng/ml and it is 19ng/ml or more in full term but with large individual differences. The total plasma estriol value, at 25 weeks of gestation, is 50ng/ml and is 200ng/ml at 40 weeks of pregnancy. At 24h, the urine estriol was 8.12 ± 0.28mg at 28 weeks of pregnancy and was 19.81 ± 8.28 mg in full term. It is generally believed that after 36 weeks of pregnancy, if the urine content at 24 h > 15mg, the value is normal; 12~10mg is alert value while <10mg is dangerous values. Since the major precursor of estriol during pregnancy comes from fetus, being different from the estrone and estradiol that is from the mother, the determination of estriol may reflect the condition of fetal development. When some fetal malformations and maternal or fetal diseases affect fetal development or cause fetal asphyxia, it is always accompanied of decrease of estriol. However, due to the great daily fluctuations of estriol level, it is generally measured for 4 to 5 times at least for some time in order to determine whether the level of estriol is really low. The estriol level in mild hypertension of pregnancy are often normal before 34 weeks while is maintained at low level after 34 weeks while the level significantly drops upon severe pregnancy-induced hypertension. For pregnant women upon exceeding the expected date, you can continuously measure the urinary estriol in 24h. If it is always higher than 25mg, you can still wait under close observation; if it is less than 10mg, the fetus is at risk and should be subject to positive treatment. Owing to lack of hypothalamus, non-brain child has pituitary hypoplasia and small adrenal gland. Since the supply of the raw material for the placental synthesis of estriol, 16-hydroxy isopropyl DHEA is in insufficient amount, the estriol in urine of pregnant women is very low with most being below the normal 10%.
Our Service
1.Cooperate with research institutions, we strictly control the process from raw material to finished product.
2.We can provide the reasonable price, high quality products and prompt shipment.
3.We can send the goods to your delivery address directly. It is relatively safe and fast.
4.Quick and clear response to customers questions, we’ll treat every email and message within 24 hours usually much faster.
5.We can provide you a discount if you place a substantial order with us.
6.Products can be packaged and company logo can be customized according to customer requirements.
Delivery
1. Sent out in 24hours once payment comfirm.
2. Professional agent make sure our ship fastly and safety
3.Offer your tracking number to you once we get it ,in order to facilitateyou track the express.
FAQ
Q1: Can i get some samples?
A: Yes, we can supply the sample, but the shipping cost be paid by ourcustomers.
Q2: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosedour bank information. Payment by T/T, Western Union or Paypal.
Q3: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay theshipping cost or arrange a courier to us and take the samples. You cansend us your product specifications and requests,we will manufacture theproducts according to your requests.
Q4:What's your MOQ?
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g onthe condition that sample charge is 100% paid.
Q5: How about delivery lead time?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chineseholiday not included)
Q6: Do You Ship Over The Weekend?
We use EMS,TNT,FEDEX,DHL four kinds of couriers. EMS don't collected parcelsover the weekend. The packages can be shipped out normally before 12:00a.m in Beijing time if you choose to ship by TNT or FedEx.
China
