High purity EIDD-2801 comes from Biolang
Basic Information
 EIDD-2801 structure | Common Name | EIDD-2801 |
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| CAS Number | 2349386-89-4 | Molecular Weight | 329.31 |
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| Density | N/A | Boiling Point | N/A |
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| Molecular Formula | C13H19N3O7 | Melting Point | N/A |
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| MSDS | N/A | Flash Point | N/A |
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| EIDD-2801 (Molnupiravir) Usage And Synthesis |
| Description | EIDD-2801 is an orally bioavailable prodrug of the antiviral nucleoside derivative N4- hydroxycytidine (NHC, EIDD-1931). It is a nucleotide analog inhibitor of RNA-dependent RNA polymerases (RdRps). The compound interferes with the action of viral RNA polymerase. It exerts its antiviral action through introduction of copying errors during viral RNA replication. The active drug incorporates into the genome of RNA viruses, leading to an accumulation of mutations known as viral error catastrophe. The broadspectrum antiviral agent EIDD-2801 inhibits viral RNA replication in various unrelated RNA viruses including influenza, Ebola, Venezuelan equine encephalitis virus (VEEV) and coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2. EIDD-2801 has the potential for COVID-19, seasonal and pandemic influenza treatment. |
| History | Molnupiravir (EIDD-2801/MK-4482) is an investigational, orally bioavailable form of a potent ribonucleoside analog that inhibits the replication of multiple RNA viruses including SARS-CoV-2, the causative agent of COVID-19. Molnupiravir has been shown to be active in several models of SARS-CoV-2, including for prophylaxis, treatment and prevention of transmission, as well as SARS-CoV-1 and MERS. EIDD-2801 was invented at Drug Innovations at Emory (DRIVE), LLC, a not-for-prot biotechnology company wholly owned by Emory University, and with partial funding support from the U.S. government. Since licensed by Ridgeback, all funds used for the development of EIDD-2801 by Ridgeback have been provided by Wayne and Wendy Holman and Merck. |
| Uses | EIDD 2801 is an orally bioavailable broad-spectrum antiviral that inhibits SARS-CoV-2 and other multiple endemic, epidemic and bat coronavirus and has the potential for seasonal and pandemic influenza treatment. An isopropylester prodrug of the ribonucleoside analog of EIDD-1931 that exhibits anti-influenza virus and coronaviruses activities. |
| Biological Activity | EIDD-2801 is an orally active, 5′-isopropylester prodrug form of the antiviral ribonucleoside analog N4-hydroxycytidine (NHC, EIDD-1931) with known anti-viral activity against SARS-CoV, SARS-CoV-2, RSV, influenza A & B (IAV & IBV), HCV, pestivirus, bovine viral diarrhoea virus (BVDV), Ebola (EBOV), Chikungunya (CHIKV), venezuelan equine encephalitis (VEEV). EIDD-2801 is efficiently hydrolyzed to NHC in vivo, being more orally bioavailable than NHC in nonhuman primates and ferrets, while maintaining similar oral bioavailability as NHC in mice. EIDD-2801 displays in vivo efficacy against pandemic and seasonal IAV strains in ferrets (lowest ED = 2.3 and 7 mg/kg b.i.d. p.o., respectively). |
| Preparation and handling | Molnupiravir is supplied as a crystalline solid. A stock solution may be made by dissolving molnupiravir in the solvent of choice, which should be purged with an inert gas. Molnupiravir is soluble in organic solvents such as DMSO and dimethyl formamide. The solubility of molnupiravir in these solvents is approximately 30 mg/ml.
Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of molnupiravir can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of molnupiravir in PBS, pH 7.2, is approximately 1 mg/ml. We do not recommend storing the aqueous solution for more than one day. |
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Our Company
Shanghai Biolang Biological Co., Ltd has a registered capital of 1 million yuan and is one of the most dynamic foreign trade companies in the Chinese market. We have a pharmaceutical raw material production plant and a reagent R&D center. We now have the most complete product line. In addition, we have developed and produced tens of thousands of reagents. We also have the business of custom synthesis of various organic compounds as a supplement. We can synthesize almost all chemicals. Our goal is to survive by quality and develop by credit.
In the past two years, our products have spread over more than 30 countries in the world, Europe, South America, North America, Southeast Asia and Africa. We work with friends all over the world to develop the best quality products, the most reasonable prices and safe and effective transportation. Product can be ordered from milligrams to tons. Meet the purchase of new and old customers. We will not let you down.
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1. Products with high purity and good quality
2. Choose the most suitable price according to customer needs to achieve a win-win situation.
3. Spot samples can be shipped quickly after payment, saving time for receiving goods.
4. Track the transportation of goods throughout the process
5. Safe raw materials from China
6. Have professional customs clearance capabilities and the best pre-sales and after-sales services.
our service
1. Cooperate with scientific research institutes and major factories to strictly control the entire process of products from raw materials to finished products
2. Customer first, we provide reasonable prices, high-quality products and timely delivery.
3. We can send the goods directly to your receiving address.
4. Quickly and accurately answer customers' doubts
5. If you place a large number of orders with us, we can provide preferential prices
6. Products can be packaged according to customer requirements.
FAQ
Q1: Can I get some samples?
Answer: Yes, we can provide free samples, but the freight is paid by our customers.
Q2: How to confirm the product quality before placing an order?
Answer: You can get samples of some products for free, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us your product specifications and requirements, and we will manufacture products according to your requirements.
Q3: How to start an order or payment?
After the order is confirmed, the PI will be sent first with our bank information. Payment via T/T, Western Union, Letter of Credit, Alibaba Trade Assurance, Cashapp, Moneygram or Bitcoin.
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You can contact me through Trademanager, WhatsApp, Skype Online and other contact methods, tell me the product and quantity you need, and we will give you a quote. If you choose one of the above payment methods, we will arrange delivery for you.
Q5: Are there any discounts?
Answer: There are different discounts for different quantities.
Q6: How about your delivery time?
Answer: Generally speaking, it will take 3 to 5 days after receiving your prepayment. (Excluding Chinese holidays)
Q6: How do you deal with quality complaints?
Answer: First of all, our quality control will reduce quality problems to close to zero. If the quality problem is indeed caused by us, we will replace it for you free of charge or refund your loss.
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