Pharmacological action:
Like other macrolide antibiotics, gamamycin prevents peptide chain extension by binding to the 50S subunit of ribosomes of sensitive bacteria, affecting the synthesis of bacterial proteins, thus playing a antibacterial and bactericidal role. Gamimycin mainly acts on pathogenic bacteria such as Mantella hemolyticus, Pasteurella multocida and histoma somnophila which cause respiratory diseases in cattle. In addition, Mycoplasma filiformis, Streptococcus equi epizoosis, Rhodococcus equi resistant to macrolides and sensitive to macrolides, mycoplasma suis and actinobacillus pleuropneumoniae, which are the pathogens of bovine infectious pleuropneumonia, have good antibacterial activity in vitro. Gamimycin has good bacteriostasis and bactericidal effects on the main pathogens causing respiratory diseases in cattle.
Preparation method:
Gamamycin was synthesized with 9-deoxy-8A-azaza-8a-homomycin A as the precursor. The final product gamamycin was prepared by SN2 substitution reaction of propane bromide with 9-deoxy-8a-aza-8a-homomycin A in the yield and content of 66.1% and 63.87%, respectively, using dichloromethane as the reaction solvent. Or gamimycin was synthesized with 9-deoxy-8α-aza-8α-homomycin A as intermediate by hydrogenation of propanal cyanoborohydride with yield of 38.1%. Using erythromycin 9, 12-imide ether as raw material and 5% Pt/C as catalyst, acetic acid reaction was added, and then propionaldehyde and acetic acid reaction were added to obtain the target product plus milomycin. The yield and purity were 79.0% and 88.9%, respectively.
Uses:
It is mainly used to prevent and treat respiratory diseases of non-lactating cattle caused by pathogenic bacteria such as Mantella hemolyticus, Pasteurella and histophila.
Bovine applications for the treatment of bovine respiratory diseases (BRD) caused by sensitive bacteria.
The application of sheep is used to control hoof rot in sheep and to treat the sudden lameness of sheep caused by streptobacterin.
Melting Point | >118°C |
Boiling Point | 833.0±65.0 °C |
Density | 1.16±0.1 g/cm3 |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
pKa | 13.42±0.70 |
Solubility | Soluble in chloroform (a little), methanol (a little) |
Our advantages:
1) Timely communication, reply within 12 hours.You can leave any messages on our whatsapp or send email to us.
2)Selecting raw materials strictly,our products are the highest purity.
3)Reasonable and competitive price.
4) Free sample for your evaluation.Customers only need to undertake the shipping fee for delivery the samples to your destionation.
5)OEM/ODM Available.Trial order is available for testing after samples.
6) Packaging can be customized according to each buyers' special request.
We guarantee that your package will pass 100% through the Mexico US, UK, Australia, Netherlands, Canada, France, Germany, Spain, Belgium, Sweden, Poland, Russian, Ukraine, Kazakhstan, Czech Republic, Slovakia, Portugal.
We have freight forwarders in these countries, and our customs clearance company will clear your parcels without any customs issues, sometimes even 1000 kg. Door to door service. Make sure you receive 100% of the goods. Let you have a good experience of our strong freight capacity.
Company Introduction
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!
After Sales Service
1) Best quality in your requirement
2)Competitive price in china market
3)Mature technical support
4)Professional logistic support
5 )Full experience of large numberscontainers loading in chinese sea port
6 )Fast shipment by reputed shipping line
7) Packing with pallet as buyer's special request
8) Best service after shipment.
9) Cargoes together with container after-sales service available
10) Full experience in export
11)Raw materials from chinese origin
FAQ
What is the way you ship?
Express: FedEx, UPS, EMS, DHL, USPS, TNT, DPD, Aramex etc
Our way of shipping the products is universal and secure.
The company name and other contents related to pharmacy are not written on the package slips.
The way of packing is regularly changed for a secure delivery.
The packages are small in order to avoid unwelcomed questions . If the order is big, then it will be divided into two or more packages
Can the packages be trackable?
YES, we provide tracking number and you can track on internet.
Where do you ship to?
Worldwide.
Do you offer domestic shipping/remail shipping?
Yes we can ship to USA/UK/Canada/Australia/Germany etc warehouse first then to you.
Do you ensure your packing , what about customs, what happens if the package is retained?
We concern a lot about our safety system, we pack the orders as secure as possible. If a package is seized at customs, reships of seized orders will be done provided you have a copy of the letter to show us. If you receive a seizure letter, please contact us immediately with a scanned copy of the seizure letter, and also a new address to have your order reshipped to.
Which payment options are available?
Bitcoin
Western Union
Bank wire
MoneyGram
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