The basic information
Chinese name: hydroxymethylenone
Chinese name: Tofacitinib citrate; 17β -hydroxy-2-hydroxymethyl-17 α -methyl-5 α -androsterone (alkane) -3-one; 2-hydroxymethylene-17 α -methylene-5 α -androstere-17 β -alcohol-3-one; 2-hydroxymethylene-17 α -methylene-5 α -androstere-17 β -alcohol-3-one; 17 beta Hydroxy - 17 - methyl - 2 - (hydroxymethylene) - 5 alpha androstan - 3 - one;
English name: Oxymetholone
English alias: Roboral; Adroidin; Stanozolol impurity B; Androstan-3-one, 17-hydroxy-2-(hydroxymethylene)-17-methyl-; Becorel; Adroyd; Oxymetholone; Anadroyd; Anadrol; Raboral;
The CAS number: 434-07-1
MDL number: MFCD00133083
EINECS no. : 207-098-6
RTECS number: BV8060000
PubChem number: 24897930
Molecular formula: C21H32O3
Formula:
Molecular weight: 332.47700
Accurate quality: 332.23500
PSA: 57.53000
LogP: 4.40100
Physical and chemical properties
Appearance and properties: white crystalline powder
Density: 1.169 g/cm3
Melting point: 172-180 ° C
Boiling point: 465.9ºC at 760mmHg
Flash: DHS 249.7 C
Refractive index: 38 ° (C=1, CHCl3)
Stability: Stability May be light sensitive. Combustible. Incompatible with strong oxidizing agents.
Storage condition: 2-8ºC
Steam pressure: 1.23E-10mmHg at 25°C
Safety information
Symbol: GHS08
Signal word: warning
Hazard statement: H351; H361
Cautionary statement: P281
Customs code: 2937290023
WGK Germany: 3
Danger class code: R40
Safety Description: S53-S22-S26-S36/37/39
RTECS number: BV8060000
Dangerous Goods Mark: T [1]
Molecular structure data
1. Molar refractive index: 95.89
2. Molar volume (m/mol) : 284.2
3, equal tension specific capacity (90.2K) : 757.0
4. Surface tension (DYNE /cm) : 50.3
5. Polarization (10cm) : 38.01
The synthetic methods
The product can be prepared by acetylation, reduction, ring opening, oxidation, hydrolysis, elimination, oxime, rearrangement, hydrolysis, addition, oxidation, hydrolysis, condensation and other multi-step reactions of saponin or sisal.
use
The intermediate of Corylon. It can promote protein synthesis and inhibit protein heterogenesis, reduce blood cholesterol, reduce calcium and phosphorus excretion, alleviate bone marrow inhibition, promote development, and promote tissue regeneration and granulation formation. It has preventive and antagonistic effect on adrenocortical dysfunction caused by long-term use of adrenocortical hormone. [2]
Compound related drug description speech
Pharmacological effects
Hydroxymethylenone can promote protein synthesis and inhibit protein allogenesis, reduce blood cholesterol, reduce calcium and phosphorus excretion, alleviate bone marrow inhibition, promote development, promote tissue regeneration and granulation formation. Its protein assimilation was 4 times that of methyl testosterone, its androgen activity was 0.39 times that of methyl testosterone, and its differentiation index was about 10.5. It has antagonistic effect on protein dissimilation caused by excessive adrenal corticosteroid, and has preventive and antagonistic effect on adrenal cortical dysfunction caused by long-term use of adrenal corticosteroid.
indications
It is used in osteoporosis, chronic wasting disease, old age and infirm, serious disease, weak and emaciated after operation, childhood hypoplasia, aplastic anemia, leukopenia, hyperlipidemia, etc.
contraindicated
Patients with liver and kidney insufficiency, prostate cancer and pregnant women are forbidden.
Usage.
Orally, 5 ~ 10mg per day, divided into 1 ~ 3 times. Dosage for children: 1.25 to 5mg per day. For osteoporosis, 2.5mg each time, 3 times a day, or up to 20mg a day. For aplastic anemia, 1 ~ 5mg/kg daily.
Adverse reactions
Occasionally see nausea, oedema, liver dysfunction and icteric. Young women occasionally delayed menstruation phenomenon, withdrawal can be restored.
Matters needing attention
1. Do not take the medicine for more than 30 days for children and less than 90 days for adults.
2. For aplastic anemia, medication time may be longer. [3]
China
