1-[2-(2-Hydroxyethoxy)ethyl]piperazine NEW

Chinese name: 2-[2-(1-piperazinyl) ethoxy] ethanol

English name: 1 - Hydroxyethylethoxypiperazine

CAS: 13349-82-1

Molecular formula: C8H18N2O2

MDL number: MFCD00074931

Molecular weight: 174.24

Appearance: reddish brown oily liquid or light yellow viscous liquid or white crystalline powder.

Appearance: Boiling point 112-114℃ (33Pa), relative density 1.061.

Boiling point: 112-114 °C0.25 mm Hg(lit.)

Density: 1.061 g/mL at 25 °C(lit.)

Refractive index: n20/D 1.497(lit.)

Flash point: > 230 °F

Storage conditions: Keep in dark place,Inert atmosphere,Room temperature

Solubility: Soluble in acetone (a little), chloroform (a little), methanol (a little)

Acidity coefficient (pKa) : 14.41±0.10(Predicted)

Form: Liquid

Specific gravity: 1.061

Color: clear colorless to yellowish brown

InChI: InChI=1S/C8H18N2O2/c11-6-8-12-7-5-10-3-1-9-2-4-10/h9,11H,1-8H2

InChIKey: FLNQAPQQAZVRDA-UHFFFAOYSA-N

SMILES: C(O)COCCN1CCNCC1

category

Pharmaceutical intermediates: piperazines

Use 1

Used as a pharmaceutical intermediate

Preparation method

Method one

It is obtained by condensation of piperazine and chloroethoxyethanol. Piperazine hexahydrate and piperazine dihydrochloride were added to the reaction pot, stirred and heated to 140℃, steamed away the water, and piperazine hydrochloride was obtained. Cool to 120℃ and add chloroethoxyethanol. Add up, heat up to 150-155℃, reaction for 4h, put in cold ethanol while hot, cool to 0-5℃. Filtrate, add sodium hydroxide solution to neutralize, filter out sodium chloride, steam ethanol, and get the finished product. The yield is 60%.